Mucopolysaccharide-Lipoprotein Complexes in Atherosclerotic Aorta

  • G. S. Berenson
  • S. R. Srinivasan
  • B. Radhakrishnamurthy
  • E. R. DalferesJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 43)


The carbohydrate macromolecules present in the arterial wall represent families of complex compounds (Berenson et al., 1971). Although widely distributed throughout the body in all mesenchymal structures, the macromolecules are particularly important to the cardiovascular system. Most studies, including our own, over the past two decades have served largely to describe connective tissue compounds taxonomically, and have not been able to clearly define their function. That connective tissue elements form an integral part of the cardiovascular system is fundamental; still, the task remains to bridge the gap between morphological, biochemical changes of connective tissues, and the functional nature of these changes.


Arterial Wall Uronic Acid Serum Lipoprotein Aortic Tissue Fatty Streak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Amenta, J.S., and Waters, L.L. (1960–1961). The precipitation of serum lipoproteins by mucopolysaccharides extracted from aortic tissue. Yale J. Biol. Med. 33, 112.Google Scholar
  2. Berenson, G.S. (1959). Distribution of acid mucopolysaccharides in inner and outer layers of bovine aorta. Circ. Res. 7, 889.Google Scholar
  3. Berenson, G.S., Radhakrishnamurthy, B., Dalferes, E.R., Jr., and Srinivasan, S.R. (1971). Carbohydrate macromolecules and atherosclerosis. Hum. Pathol. 2, 57.Google Scholar
  4. Berenson, G.S., Srinivasan, S.R., Lopez-S., A., Radhakrishnamurthy, B., Pargaonkar, P.S., and Deupree, R.H. (1972a). Clinical application of an indirect method for quantitating serum lipoproteins. Clin. Chim. Acta 36, 175.Google Scholar
  5. Berenson, G.S., Srinivasan, S.R., Pargaonkar, P.S., Radhakrishnamurthy, B., and Dalferes, E.R., Jr. (1972b). A simplified primary screening procedure for the detection of hyperlipidemias in “normal” individuals. Clin. Chem. 18, 1463.Google Scholar
  6. Bernfeld, P., Nisselbaum, J.S., Berkeley, B.J., and Hanson, R.W. (1960). The influence of chemical and physiochemical nature of macromolecular polyanions on their interaction with human serum ß-lipoproteins. J. Biol. Chem. 235, 2852.Google Scholar
  7. Bihari-Varga, M., and Vegh, M. (1967). Quantitative studies on the complexes formed between aortic mucopolysaccharides and serum lipoproteins. Biochim. Biophys. Acta 144, 202.Google Scholar
  8. Bunting, C.H., and Bunting, H. (1953). Acid mucopolysaccharides of the aorta. Arch. Pathol. 55, 257.Google Scholar
  9. Burstein, M., and Samaille, J. (1955). Sur la clarification du serum lipemique par l’heparin in vitro. C.R. Acad. Sci. ( Paris ), 241, 664.Google Scholar
  10. Cornwell, D.G., and Kruger, F.A. (1961). Molecular complexes in the isolation and characterization of plasma lipoproteins. J. Lipid Res. 2, 110.PubMedGoogle Scholar
  11. Dalferes, E.R., Jr., Ruiz, H., Kumar, V., Radhakrishnamurthy, B., and Berenson, G.S. (1971). Mucopolysaccharides of fatty streaks in young human male aortas. Atherosclerosis 13, 121.PubMedCrossRefGoogle Scholar
  12. Gresham, G.A., and Howard, A.N. (1961). The histogenesis of the atherosclerotic “fatty streak.” J. Atheroscler. Res. 1, 413.Google Scholar
  13. Hauss, W.H., Gerlach, G., Junge-Hülsing, H., Themann, H., and Wirth, W. (1969). Studies on the “nonspecific mesenchymal reaction” and the “transit zone” in myocardial lesions and atherosclerosis. Ann. N.Y. Acad. Sci. 156, 207.Google Scholar
  14. Iverius, P.H. (1972). The interaction between human plasma lipoproteins and connective tissue glycosaminoglycans. J. Biol. Chem. 247, 2607.Google Scholar
  15. Kramsch, D.M., and Hollander, W. (1973). The interaction of serum and arterial intima and its role in the lipid accumulation in atherosclerotic plaques. J. Clin. Invest. 52, 236.Google Scholar
  16. Kumar, V., Berenson, G.S., Ruiz, H., Dalferes, E.R., Jr., Strong, J.P. (1967a). Acid mucopolysaccharides of human aorta: II. Variations with atherosclerotic involvement. J. Atheroscler. Res. 7, 573.Google Scholar
  17. Kumar, V., Berenson, G.S., Ruiz, H., Dalferes, E.R., Jr., Strong, J.P. (1967b). Acid mucopolysaccharides of human aorta: I. Variations with maturation. J. Atheroscler. Res. 7, 573.Google Scholar
  18. Meyer, K., Davidson, E., Linker, A., and Hoffman, P. (1956). Acid mucopolysaccharides of connective tissue. Biochem. Biophys. Acta 21, 506.Google Scholar
  19. Mórner, K.T. (1895). Einige Beobachtungen über die Verbreitung der Chondroitin-Schwefelsäure. Z. Physiol. Chem. 20, 357.Google Scholar
  20. Rinehart, J.F. (1954). Observations on the histogenesis and pathogenesis of arteriosclerosis. In “Connective Tissue in Health and Disease.” (G. Asboe-Hansen, ed.), pp. 239–250. Ejnar Munksgaard, Copenhagen.Google Scholar
  21. Ross, R., and Glomset, J.A. (1973). Atherosclerosis and the arterial smooth muscle cell. Science 180, 1332.PubMedCrossRefGoogle Scholar
  22. Smith, E.B., Evans, P.H., and Downham, M.D. (1967). Lipids in the aortic intima: The correlation of morphological and chemical characteristics. J. Atheroscler. Res. 7, 171.Google Scholar
  23. Smith, E.B., Slater, R.S., and Chu, P.K. (1968). The lipids in raised fatty and fibrous lesions in human aorta: A comparison of the changes at different stages. J. Atheroscler. Res. 8, 399.Google Scholar
  24. Srinivasan, S.R., Dolan, P., Radhakrishnamurthy, B., and Berenson, G.S. (1972). Isolation of lipoprotein acid mucopolysaccharide complexes from fatty streaks of human aortas. Atherosclerosis 16, 95.PubMedCrossRefGoogle Scholar
  25. Srinivasan, S.R., Lopez-S., A., Radhakrishnamurthy, B., Berenson, G.S. (1970). Complexing of serum -lipoproteins and acid mucopolysaccharides. Atherosclerosis 12, 321.Google Scholar
  26. Taylor, H.E. (1953). The role of mucopolysaccharides in the pathogenesis of intimal fibrosis and atherosclerosis of the human aorta. Amer. J. Pathol. 29, 871.Google Scholar
  27. Tracy, R.E., Merchant, E.B., and Kao, V.C. (1961). On the antigenic identity of human serum beta and alpha-2 lipoproteins, and their identification in aortic intima. Circ. Res. 9, 472.Google Scholar
  28. Virchow, R. (1856). Gesammelte Abhandlungen zur Wissenschaftlichen Medizin. Meidinger Sohn u. Comp., Frankfurt a.M.Google Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • G. S. Berenson
    • 1
  • S. R. Srinivasan
    • 1
  • B. Radhakrishnamurthy
    • 1
  • E. R. DalferesJr.
    • 1
  1. 1.Departments of Medicine and BiochemistryLouisiana State University School of MedicineNew OrleansUSA

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