The Macromolecules of the Intercellular Matrix of the Arterial Wall: Collagen, Elastin, Proteoglycans, and Glycoproteins

  • L. Robert
  • A. Kadar
  • B. Robert
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 43)


The arterial wall can be considered as differentiated connective tissue. Three main cell types have been described and characterized as the normal constituents of major arteries; they are the smooth muscle cells of the media, the endothelial cells limiting the intima toward the blood stream, and the “fibroblasts” in the adventitia of large arteries such as the aorta.


Arterial Wall Heparan Sulfate Elastic Fiber Dermatan Sulfate Rabbit Aorta 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Albert, E.N. (1972). Amer. J. Pathol. 69, 89.Google Scholar
  2. Anastassiades, T., Anastassiades, P.A., and Denstedt, O.F. (1972). Biochim. Biophys. Acta 261, 418.Google Scholar
  3. Anderson, A.J. (1963). Biochem. J. 88, 460.PubMedGoogle Scholar
  4. Balazs, E.A. (1970). “Chemistry and Molecular Biology of the Intercellular Matrix,” Vols. 1–3. Academic Press, New York.Google Scholar
  5. Banga, I. (1969). In “International Symposium Biochemistry of the Vascular Wall, Fribourg, 1968,” (M. Comel and L. Laszt, eds.). pp. 18–92 (202–276). Karger, Basel.Google Scholar
  6. Barnes, M.J., and Partridge, S.M. (1968). Biochem. J. 109, 883.PubMedGoogle Scholar
  7. Beaumont, J.L. (1970). Eur. J. Clin. Biol. Res. 15, 1037.Google Scholar
  8. Beaumont, J.L., Beaumont, V., and Antonucci, M. (1969). C.R. Acad. Sci. (Paris) 268, 1830.Google Scholar
  9. Beaumont, V., and Beaumont, J.L. (1968). Pathol. Biol. 16, 869.Google Scholar
  10. Bentley, J.P., Wuthrich, R.C., and Van Bueren, A.M. (1970). Atherosclerosis 12, 159.PubMedCrossRefGoogle Scholar
  11. Berenson, G.S., Radhakrishnamurthy, B., Fishkin, A.F., Dessauer, H., and Arquembourg, P. (1966). J. Atheroscler. Res. 6, 214.PubMedCrossRefGoogle Scholar
  12. Berry, C.L., Looker, T., and Germain, J. (1972). J. Anat. 113, 1.PubMedGoogle Scholar
  13. Bihari-Varga, M., Gergely, J., and Gero, S. (1964). J. Atheroscler. Res. 4, 106.PubMedCrossRefGoogle Scholar
  14. Bihari-Varga, M., and Gero, S. (1966). Acta Physiol. Acad. Sci. Hung. 29, 273.Google Scholar
  15. Bihari-Varga, M., and Vegh, M. (1967). Biochim. Biophys. Acta 144, 202.Google Scholar
  16. Bouissou, H., Pieraggi, M.T., Julian, M., and Douste, B.L. (1973). In “Frontiers in Matrix Biology.” Vol. 1. “Aging of Connective Tissue Skin.” eds. L. Robert and B. Robert. Karger, Basel.Google Scholar
  17. Carnes, W. (1972). In “The Comparative Molecular Biology of Extracellular Matrices.” (H.C. Slavkin, ed.). p. 400. Academic Press, New York.Google Scholar
  18. Crossley, H.L., Johnson, A.R., Mauger, K.K., Wood, N.L., and Fuller, G.C. (1972). Life Sci. 11, 869.CrossRefGoogle Scholar
  19. Ebel, A., Kempf, E., Bollack, Cl., and Mandel, P. (1970). Atherosclerosis 12, 219.PubMedCrossRefGoogle Scholar
  20. Engel, U.R. (1971). Atherosclerosis 13, 45.PubMedCrossRefGoogle Scholar
  21. Fischer, G.M., and Llaurado, J.G. (1967). Arch. Pathol. 84, 95.PubMedGoogle Scholar
  22. Fischer, G.M., and Llaurado, J.G. (1966). Circ. Res. 19, 394.PubMedGoogle Scholar
  23. Fishkin, A.F., and Spangler, P.N. (1968). Nature 218, 577.PubMedCrossRefGoogle Scholar
  24. Fitch, S.M., Harkness, M.L., and Harkness, R.D. (1955). Nature 176, 163.PubMedCrossRefGoogle Scholar
  25. Frey, J. (1969). “Contribution à la Connaissance du Métabolisme Physiologique du Collagene fondée sur une Etude de la Biosynthése de l’Hydroxyproline Protéinique,” These Fac. Sci. Univ. Lyon.Google Scholar
  26. Frey, J., Farjanel, J., and Crouzet, B. (1969). Bull. Soc. Chim. Biol. 51, 471.PubMedGoogle Scholar
  27. Gan, J.C., Narashimha Murthy, P.V., Nichols, C.W., Jr., and Chaikoff, I.L. (1967). J. Atheroscler. Res. 7, 629.PubMedCrossRefGoogle Scholar
  28. Gardais, A., Picard, J., and Hermelin, B. (1973). Comp. Biochem. Physiol. 44B, 507.Google Scholar
  29. Gardais, A., Picard, J., and Tarasse, C. (1969). J. Chromatogr. 42, 396.PubMedCrossRefGoogle Scholar
  30. Gers, S. (1964). Symp. Zool. Soc. Lond. 11, 169.Google Scholar
  31. Gera, S., Virag, S. Bihari-Varga, M., Székely, J., and Fehér, J. (1967). Progr. Biochem. Pharmacol. 2, 290.Google Scholar
  32. Gerrity, R.G., and Cliff, W.J. (1972). Exp. Mol. Pathol. 16, 382.PubMedCrossRefGoogle Scholar
  33. Grant, M.E., Steven, F.S., Jackson, D.S., and Sandberg, L.B. (1971). Biochem. J. 121, 197.PubMedGoogle Scholar
  34. Grant, R.A. (1967). J. Atheroscler. Res. 7, 463.PubMedCrossRefGoogle Scholar
  35. Guidollet, J., and Louisot, P. (1973). Clin. Chim. Acta 43, 157.PubMedCrossRefGoogle Scholar
  36. Harkness, R.D. (1961). Biol. Rev. 36, 399.PubMedCrossRefGoogle Scholar
  37. Hauss, W.H., and Junge-Hûlsing, G. (1963). Exp. Ann. Biochim. Med. 24, 239.Google Scholar
  38. Hauss, W.H. (1973). Arch. Abt. A. Pathol. Anat. 359, 135.Google Scholar
  39. Haust, M.D., and Geer, J.C. (1970). Amer. J. Pathol. 60, 329.Google Scholar
  40. Haust, M.D., More, R.H., Bencosme, S.G., and Balis, J.U. (1967). Exp. Mol. Pathol. 6, 300.PubMedCrossRefGoogle Scholar
  41. Henry, J.C. (1968). C.R. Acad. Sci. (Paris) 266, 1449.Google Scholar
  42. Hoffman, A.S. (1971). In “Biomaterials” (A.L. Bement, Jr., ed.). pp. 285–312. University of Washington Press, Seattle.Google Scholar
  43. Ichida, T., and Kalant, N. (1968). Can. J. Biochem. 46, 249.PubMedGoogle Scholar
  44. Iverius, P.H. (1968). Clin. Chim. Acta 20, 261.PubMedCrossRefGoogle Scholar
  45. Jackson, D.S., Sandberg, L.B., and Cleary, E.G. (1966). Nature 210, 195.PubMedCrossRefGoogle Scholar
  46. Jacotot, B., Beaumont, J.L., Monnier, G., Szigeti, M., Robert, B., and Robert, L. (1973). Nutr. Metabol. 15, 46.CrossRefGoogle Scholar
  47. Janoff, A. (1970). Ser. Haematol. 3, 96.PubMedGoogle Scholar
  48. Junge-Hulsing, G., and Wagner, H. and Skeletal Tissue, 1968.“ 3rd. (Arthur Engle and Tage Nordiska Bokhandelns Forlag, (1969). In ”Aging of Connective Thule International Symposia, Larson, eds.). pp. 213–228. Stockholm.Google Scholar
  49. Junqua, S., Fayolle, J., and Robert, L. (In preparation).Google Scholar
  50. Kadar, A., Gardner, D.L., and Bush, V. (1971). J. Pathol. 104, 253.PubMedCrossRefGoogle Scholar
  51. Kadar, A., Robert, B., and Robert, L. (In press). Pathol. Biol.Google Scholar
  52. Kadar, A., Veress, B., and Jellinek, H. (1969). Exp. Mol. Pathol. 11, 212.PubMedCrossRefGoogle Scholar
  53. Kaplan, D., and Meyer, K. (1960). Proc. Soc. Exp. Biol. Med. 105, 78.Google Scholar
  54. Knieriem, H.J., Kap, V.C.Y., and Wissler, R.W. (1968). J. Atheroscler. Res. 8, 125.PubMedCrossRefGoogle Scholar
  55. Kornfeld-Poullain, N., and Robert, L. (1968). Bull. Soc. Chim. Biol. 50, 759.PubMedGoogle Scholar
  56. Kresse, H., Heidel, H., and Buddecke, E. (1971). Eur. J. Biochem. 22, 557.PubMedCrossRefGoogle Scholar
  57. Kulonen, E., and Pikkarainen (In press). “Biology of the Fibroblast.” Academic Press, New York.Google Scholar
  58. Kumar, V., Berenson, G.S., Ruiz, H., Dalferes, E.R., and Strong, J.P. (1967). J. Atheroscler. Res. 7: 573, 583.PubMedCrossRefGoogle Scholar
  59. Lalich, J.J., and Whang Paik, W.C. (1968). Proc. Soc. Exp. Biol. Med. 127, 543.Google Scholar
  60. Lansing, A.L. (1966). Arch. Mal. Coeur Vaiss. 8, Suppl. 2, 23.Google Scholar
  61. Lee, K.T., Jones, R., Kim, D.N., Florentin, R., Coulston, F., and Thomas, W.A. (1966). Exp. Mol. Pathol. 5, Suppl. 3, 108.Google Scholar
  62. Legrand, Y., Caen, J., Booyse, F.M., Rafelson, and Robert, L. (1973). Biochim. Biophys. M.E., Robert, B., Acta 309, 406.Google Scholar
  63. Le Lievre, C., and Le Douarin, N. (1973). C.R. 276, 383. Acad. Sci. (Paris)Google Scholar
  64. Lindy, S., Turto, H., Uitto, J., Helin, P., and Lorenzen, I. (1972). Circ. Res. 30, 123.PubMedGoogle Scholar
  65. Looker, T., and Berry, C.L. (1972). J. Anat. 113, 17.PubMedGoogle Scholar
  66. McCullagh, K.G., Derouette, S., and Robert L. (1973). Exp. Mol. Pathol. 18, 202.PubMedCrossRefGoogle Scholar
  67. McCully, K.S. (1972). Amer. J. Pathol. 66, 83.Google Scholar
  68. McCully, K.S. (1971). Nature 231, 391.PubMedCrossRefGoogle Scholar
  69. Moczar, M. (1968). Glycoprotéides de la Trame Fibreuse de la paroi Artérielle, Thèse Fac. Sci. Lille.Google Scholar
  70. Moczar, M., Moczar, E., and Robert L. (1970). Atherosclerosis 12, 31.PubMedCrossRefGoogle Scholar
  71. Moczar, M., and Robert, L. (1970). Atherosclerosis 11, 7.PubMedCrossRefGoogle Scholar
  72. Moschetto, Y., and Havez, R. (1969). Bull. Soc. Chim. Biol. 51, 1171.PubMedGoogle Scholar
  73. Mukherjee, D.P., and Hoffman, A.S. (1971). In “Biophysical Properties of the Skin.” (H.R. Elden, ed.). pp. 219–241. John Wiley & Sons, New York.Google Scholar
  74. Mullinger, R.N., and Manley, G. (1969). J. Atheroscler. Res. 9, 108.PubMedCrossRefGoogle Scholar
  75. Nakamura, T., Tokita, K., Tateno, S., Kotoku, T., and Ohba, T. (1968). J. Atheroscler. Res. 8, 891.PubMedCrossRefGoogle Scholar
  76. Neuman, R.E., Logan, M.A. (1950). J. Biol. Chem. 184,299.PubMedGoogle Scholar
  77. Nimni, M.E., Guía, E., Bavetta, L.A. (1967). Biochem. J. 102, 143.PubMedGoogle Scholar
  78. Partridge, S.M. (1963). Exp. Ann. Biochim. Med. 24, 133.Google Scholar
  79. Partridge, S.M. (1970). In “Chemistry and Molecular Biology of the Intercellular Matrix.” (E.A. Balazs, ed.). Vol. 1. pp. 593–616. Academic Press, New York.Google Scholar
  80. Partridge, S.M. (1972). In “The Comparative Molecular Biology of Extracellular Matrices.” (H.C. Slavkin, ed.). p. 388. Academic Press, New York.Google Scholar
  81. Pernis, B., and Clerici, E. (1957). Experientia 13, 351.PubMedCrossRefGoogle Scholar
  82. Peters, T.J., Muller, M., and de Duve, C.J. (1972). J. Exp. Med. 136, 1117.PubMedCrossRefGoogle Scholar
  83. Picard, J., Lacord-Bonneau, M., and Gardais, A. (1968). In “Le Role de la Paroi Artérielle dans l’Athérogénèse, Paris, 1967.” Centre national de la recherche scientifique, Paris. Colloques internationaux, 169. pp. 721–734.Google Scholar
  84. Poullain, N., and Robert, L. (1966). In “Symposium International sur la Biochimie et la Physiologie du Tissu Conjonctif, Lyons, 1965.” (Ph. Comte, ed.). pp. 139–143. Lyon.Google Scholar
  85. Robert, L., Robert, B., and Robert, A.M. (1970c). Exp. Gerontol. 5, 339.CrossRefGoogle Scholar
  86. Richard, M., Broquet, P., and Louisot, P. (1972). C.R. Acad. Sci. (Paris) 274, 1212;Google Scholar
  87. Richard, M., Broquet, P., and Louisot, P. (1972). J. Mol. Cell. Cardiol. 4, 465.PubMedCrossRefGoogle Scholar
  88. Robert, A.M., Grosgogeat, Y., Reverdy, V., Robert, B., and Robert, L. (1971a). Atherosclerosis 13, 427.CrossRefGoogle Scholar
  89. Robert, A.M., Robert, B., and Robert, L. (1969). Arch. Mal. Coeur Vaiss. 62, 25.Google Scholar
  90. Robert, B., and Robert, A.M. (1969). Med. Hyg. 27, 822.Google Scholar
  91. Robert, B., Robert, A.M., and Robert, L. (In press). In “Les Glycoconjugués.” Centre national de la recherche scientifique, Paris. Colloques internationaux. (J. Montreuil and G. Spik, eds.).Google Scholar
  92. Robert, B., Szigeti, M., Derouette, J.C., Robert, L., Bouissou, H., and Fabre, M.T. (1971b). Eur. J. Biochem. 21, 507.CrossRefGoogle Scholar
  93. Robert, B., Szigeti, M., Robert, L., Legrand, Y., Pignaud, G., and Caen, J. (1970a). Nature 227, 1248.CrossRefGoogle Scholar
  94. Robert, L. (1970). In “Atherosclerosis. ” Proceedings from the Second International Symposium, 1969. (R.J. Jones, ed.). pp. 59–68. Springer-Verlag, Berlin.Google Scholar
  95. Robert, L., and Comte, P. (1968). Life Sci. 7, 493.CrossRefGoogle Scholar
  96. Robert, L., Darrell, R.W., and Robert, B. (1970a). In “Chemistry and Molecular Biology of the Intercellular Matrix.” (E.A. Balazs, ed.). Vol. 3. pp. 1591–1614. Academic Press, New York.Google Scholar
  97. Robert, L., Grosgogeat, Y., Robert, A.M., and Robert, B. (1971c). Israel J. Med. Sci. 7, 431.Google Scholar
  98. Robert, L., Junqua, S., Robert, A.M., Moczar, M., and Robert, B. (In press). In “Biology of the Fibroblast.” (E. Kulonen and J. Pikkarainen, eds.). Academic Press, New York.Google Scholar
  99. Robert, L., and Parlebas, J. (1965). Bull. Soc. Chim. Biol. 47, 1853.PubMedGoogle Scholar
  100. Robert, L., Parlebas, J., Oudea, P., Zweibaum, A., and Robert, B. (1965). In “Structure and Function of Connective and Skeletal Tissue.” NATO - Advanced Study Institute, 1964. (S. Fritton Jackson, ed.). pp. 406–412. Butterworth, London.Google Scholar
  101. Robert, L., Parlebas, J., Poullain, N., and Robert, B. (1963). “Protides of Biological Fluids.” Vol. 11. pp. 109–113. Elsevier, Amsterdam.Google Scholar
  102. Robert, L., and Poullain, N. (1963). Bull. Soc. Chim. Biol. 45, 1317.PubMedGoogle Scholar
  103. Robert, L., and Poullain, N. In “Enzymologie et Immunologie dans l’athêrosclêrose.” Colloque Bordeaux, 1964. (H. Bricaud, ed.). pp. 123–129. Bailleres, Paris.Google Scholar
  104. Robert, L., and Robert, B. (In press). In “Différenciation des Cellules Eukaryotes en Culture.” Colloque INSERM Juin 1973, Crêteil.Google Scholar
  105. Robert, L., In “La Paris, Paris. Robert, M., Moczar, M., and Moczar, E. (1968). Rôle de la Paroi Artérielle dans l’Athérogénése, 1967.” Centre national de la recherche scientifique, Colloques internationaux. pp. 395–424.Google Scholar
  106. Robert, L., Stein, F., Pezess, M.P., and Poullain, N. In “Enzymologie et Immunologie dans l’Athérosclérosis.” Pathol. 13, 79. Comparative Molecular Biology ofGoogle Scholar
  107. Colloque Bordeaux, 1964. (H. Bricaud, ed.). pp. 233–241. Brailleres, Paris.Google Scholar
  108. Sandberg, L.B., Weissman, N., and Smith, D.W. (1969). Biochemistry 8, 2940.PubMedCrossRefGoogle Scholar
  109. Schoenebeck, L., Werber, U., and Voigt, K.D. (1962). J. Atheroscler. Res. 2, 332.CrossRefGoogle Scholar
  110. Schorah, C.J., Lovell, D., and Curran, R.C. (1968). Brit. Exp. Pathol. 49, 574.Google Scholar
  111. Shimamura, T. (1970). Exp. MolGoogle Scholar
  112. Slavkin, H.C. (1972). In “The Extracellular Matrices.” Srinivasan, S.R., Dolan, P., Radhakrishnamurthy, B., and Berenson, G.S. (1972). Prep. Biochem. 2, 83; Atherosclerosis 16, 95.Google Scholar
  113. Srinivasan, S.R., Radhakrishnamurthy, B., Pargaonkar, P.S., and Berenson, G.S. (1971). Nature 229, 58.PubMedCrossRefGoogle Scholar
  114. Stein, F., Pezess, M.P., Robert, L., and Poullain, N. (1965). Nature 207, 312.PubMedCrossRefGoogle Scholar
  115. Tsiganos, C.P., and Muir, H. (1970). In “Chemistry and Molecular Biology of the Intercellular Matrix.” (E.A. Balazs, ed.). Vol. 2. pp. 859–866. Academic Press, New York.Google Scholar
  116. Velican, C. (1966). Biochim. Biol. Sper. 5, 151.Google Scholar
  117. Velican, C. (1967). J. Atheroscler. Res. 7, 517.PubMedCrossRefGoogle Scholar
  118. Viidik, A., Holm-Pedersen, P., and Rundgren, A. (1972). Scand. J. Plast. Reconstr. Surg. 6, 114. Google Scholar
  119. Warren, L. (In press). “Différenciation des Cellules Eukaryotes en Culture, Colloque INSERM Juin 1973, Créteil.Google Scholar
  120. Wirtschafter, Z.T., and Bentley, J.P. (1965). Arch. Pathol. 79, 635.PubMedGoogle Scholar
  121. Wissler, R,W. (1967). Circulation 36, 1.Google Scholar
  122. Wolinsky, H. (1972). Circ. Res. 30, 301.PubMedGoogle Scholar
  123. Wortman, B., Lee, K.T., Kim, D.N., Daoud, A.S., and Thomas, W.A. (1966). Exp. Mol. Pathol., Suppl. 3, 88.Google Scholar
  124. Zemplenyi, T. (1968). “Enzyme Biochemistry of the Arterial Wall.” Lloyd-Luke, London.Google Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • L. Robert
    • 1
    • 2
    • 3
  • A. Kadar
    • 1
    • 2
    • 3
  • B. Robert
    • 1
    • 2
    • 3
  1. 1.Laboratoire de Biochimie du Tissu Conjonctif Faculté de MedecinéUniversité Paris-Val de MarneCréteilFrance
  2. 2.Institute of Pathological AnatomyII. Medical Faculty of the Semmelweis University of BudapestHungary
  3. 3.Laboratoire de Biochimie du Tissu Conjonctif Faculté de MédecineUniversité Paris-Val de MarneCréteilFrance

Personalised recommendations