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Proliferation of Arterial Cells in Atherosclerosis

  • H. C. Stary
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 43)

Abstract

The role of cell proliferation in atherosclerosis has received much attention. It has been suggested for many years that the increase in cells during the formation of intimal lesions may be due to intrinsic proliferation. This hypothesis was based mainly on the observation of mitotic figures in the smooth muscle and foam cells of atherosclerotic plaques, even though mitoses were seen only rarely. On the other hand, it was proposed but never definitely established that migration of cells from the circulation, endothelium or media accounts for the cellular growth of the lesions. Monocytes, endothelial cells, and medial smooth muscle cells thus have been implicated.

Keywords

Smooth Muscle Cell Foam Cell Serum Cholesterol Level Tritiated Thymidine Fatty Streak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • H. C. Stary
    • 1
  1. 1.Department of PathologyLouisiana State University School of MedicineNew OrleansUSA

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