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Reaction Patterns of Intimal Mesenchyme to Injury, and Repair in Atherosclerosis

  • M. Daria Haust
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 43)

Abstract

The role of the arterial wall itself in the inception and progression of atherosclerotic lesions had been disregarded for many decades. It became apparent, however, that one had to take into consideration factors pertaining to the organ in which atherosclerotic tissue changes took place, if one hoped to account ultimately for all features of the disease process. For example, the striking variations in the degree and extent of involvement and type of atherosclerotic lesions in different arteries or in various segments of the same artery, and the range in severity in different individuals of the same age group or in the many populations of the world, cannot be accounted for by any one theory on the etiology and pathogenesis of atherosclerosis (Haust and More, 1972), or by the more modern approach of “grouping” of factors, such as those referring to several blood constituents or to hemodynamics (Haust, 1971a). The key issue is then, if by taking into consideration the factors of arterial wall at least some of the remaining problems can be solved.

Keywords

Smooth Muscle Cell Atherosclerotic Plaque Arterial Wall Atherosclerotic Lesion Reaction Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • M. Daria Haust
    • 1
    • 2
  1. 1.Department of PathologyUniversity of Western OntarioLondonCanada
  2. 2.Sir William Dunn School of PathologyUniversity of OxfordOxfordGreat Britain

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