Morphology of Mesenchymal Elements of Normal Artery, Fatty Streaks, and Plaques

  • Jack C. Geer
  • William S. Webster
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 43)


The objective of this paper is to review briefly normal arterial structure and the cells found in the various types of human atherosclerotic lesions, and to contrast the cellular reaction of human lesions with that in certain experimental models. There is a striking similarity between the mesenchymal cell reaction in human lesions and that in the experimental models, indicating that the models are valid for studying certain aspects of the pathogenesis of atherosclerosis. Our studies support the conclusion of many other investigators (Altschul, 1950; Björkerud, 1969; Hassler, 1970; Jores, 1924; Lee et al., 1970; McMillan and Stary, 1968; Poole et al., 1971) that the source of the mesenchymal or smooth muscle cells in the intima is medial cells that have proliferated and migrated into the intima.


Smooth Muscle Cell Foam Cell Rough Endoplasmic Reticulum Intimal Thickening Fatty Streak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Jack C. Geer
    • 1
  • William S. Webster
    • 1
  1. 1.Departments of Pathology and Veterinary Clinical SciencesThe Ohio State UniversityColumbusUSA

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