Abstract
The objective of this paper is to review briefly normal arterial structure and the cells found in the various types of human atherosclerotic lesions, and to contrast the cellular reaction of human lesions with that in certain experimental models. There is a striking similarity between the mesenchymal cell reaction in human lesions and that in the experimental models, indicating that the models are valid for studying certain aspects of the pathogenesis of atherosclerosis. Our studies support the conclusion of many other investigators (Altschul, 1950; Björkerud, 1969; Hassler, 1970; Jores, 1924; Lee et al., 1970; McMillan and Stary, 1968; Poole et al., 1971) that the source of the mesenchymal or smooth muscle cells in the intima is medial cells that have proliferated and migrated into the intima.
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Geer, J.C., Webster, W.S. (1974). Morphology of Mesenchymal Elements of Normal Artery, Fatty Streaks, and Plaques. In: Wagner, W.D., Clarkson, T.B. (eds) Arterial Mesenchyme and Arteriosclerosis. Advances in Experimental Medicine and Biology, vol 43. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3243-5_2
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DOI: https://doi.org/10.1007/978-1-4684-3243-5_2
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