Immunological Properties of Connective Tissue and Smooth Muscle Cells

  • J. Renais
  • P. Hadjiisky
  • L. Scebat
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 43)


Previous data from our laboratory have suggested the hypothesis that injury to the arterial wall precedes experimental arterial lesions which closely mimic human atherosclerosis. In order to test this hypothesis we attempted to injure the rat aorta by injections of rabbit antiserum antirat aorta (Scebat et al., 1964a). We found that injections of rat aorta homogenates led to a generalized arteriosclerosis in sensitized rabbits (Scebat et al., 1964b). This finding prompted us to further investigations, the results of which are the subject of this report.


Arterial Wall Elastic Fiber Alcian Blue Aortic Tissue Immune Serum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Adams, C.W.M., Bayliss, O.B., and Orton, C.C. (1967). J. Atherosclér. Res. 7, 567.Google Scholar
  2. Astrup, T. (1968). In “Le Rôle de la Paroi Artérielle dans l’Athérogénèse.” p. 535. C.N.R.S., Paris.Google Scholar
  3. Beaumont, V., and Beaumont, J.L. (1968). Pathol. Biol. 16, 869.Google Scholar
  4. Bricaud, H. (Personal Communication).Google Scholar
  5. Burnet, M. (1959). Brit. Med. J. 2, 720.PubMedCrossRefGoogle Scholar
  6. Carlson, R.G., Lillehei, C.W., and Edwards, J.E. (1970). Amer. J. Cardiol. 25, 411.PubMedCrossRefGoogle Scholar
  7. Cochrane, C.C. (1971). J. Exp. Med. 134, 75.PubMedCrossRefGoogle Scholar
  8. Comfort, A. (1961). Amer. Heart J. 62, 293.CrossRefGoogle Scholar
  9. Dixon, F. (1963). Harvey Lecture 58, 21.Google Scholar
  10. Duguid, J.B. (1946). J. Pathol. Bact. 58, 207.CrossRefGoogle Scholar
  11. Hadjiisky, P., Scebat, L., Renais, J., Cachera, J.P., Dubost, C., and Lenegre, J. (1971). Revue Europ. Etud. Clin. Biol. 16, 596.Google Scholar
  12. Hadjiisky, P., Renais, J., and Scebat, L. (1972). Pathol. Europ. 7, 131.Google Scholar
  13. Hamburger, J., Crosnier, J., and Dormont, J. (1967). Ann. N.Y. Acad. Sci. 120, 538.Google Scholar
  14. Hauss, W.H., Junge-Hulsing, G., and Gerlach, U. (1968). In “Le Role de la Paroi Artérielle dans l’Athérogênêse.” p. 745, C.N.R.S. Paris.Google Scholar
  15. Hillion, P., Renais, J., Hadjiisky, P., Maurice, P., and Scebat, L. (1969). Revue l’Athérosclér. Arteriopathies Peripheriques 11, 58.Google Scholar
  16. Knieriem, H.J., Kaov, C.Y., and Wissler, R.W. (1967). Arch. Pathol. 84, 118.PubMedGoogle Scholar
  17. Leandri, J., Cachera, J.P., Locombe, M., Bui-Mong-Hung, Vigano, M., and Haradas, S. (1967). Pathol. Biol. 15, 501.PubMedGoogle Scholar
  18. Lojda, Z. (1965). In “Morphology and Histochemistry of the Vascular Wall.” International Symposium, Fribourg, 1965. ( Comel, M., and Laszt, L., eds.) Vol. II., Karger, Basel, N. Y.Google Scholar
  19. Milgrom, F., Intorp, H.N., and Witebsky, T. (1967). J. Immunol. 99, 164.PubMedGoogle Scholar
  20. Mitchell, J.R.A., and Schwartz, C.J. (1965). In “Arterial Disease.” Blackwell, Oxford.Google Scholar
  21. Moschetto, Y., Davril, M., and Biserte, G. (1969). Revue l’Atheroscler. Arteriopathies Peripheriques 11, 44.Google Scholar
  22. Porter, K.A., Owen, K., Mowbray, J.F., Thomson, W.F., Kenyon, J.R., and Peart, W.S. (1963). Brit. Med. J. 14, 639.Google Scholar
  23. Parker, F. (1960). Amer. J. Pathol. 36, 19.Google Scholar
  24. Postnov, J.W. (1966). Virchow. Arch. Pathol. Anat. Physiol. 341, 237.Google Scholar
  25. Renais, J., Groult, N., Scebat, L., and Lenegre, J. (1968). In“Le Role de la Paroi Artêrielle dans 1’Athêrogénése.” p. 323. C.N.R.S., Paris.Google Scholar
  26. Robert, L., Robert, M., Moczar, M., and Moczar, E. (1968). In “Le Rôle de la Paroi Artêrielle dans l’Athêrogénêse.” p. 395. C.N.R.S., Paris.Google Scholar
  27. Robert, A.M., Grosgogeat, Y., Reverdy, V., Robert, B., and Robert, L. (1971). Atherosclerosis 13, 427.PubMedCrossRefGoogle Scholar
  28. Robertson, A.L. (1967). In “Lipid Metabolism in Tissue Culture Cells.” Wistar Institute Symposium, Philadelphia, 1966. (Rothblat, G.H., and Kritchevsky, D. eds.) Vol. 6, 115.Google Scholar
  29. Rossen, R.D., Butler, W.T., Reisberg, M.A., Brooks, D.K., Leachman, R.D., Milam, J.D., Mittal, K.K., Montgomery, J.R., Nora, J.J., and Rochelle, D.G. (1971). J. Immunol. 106, 171.PubMedGoogle Scholar
  30. Rottino, A. (1940). Amer. Heart J. 19, 330.CrossRefGoogle Scholar
  31. Scebat, L., Renais, J., Groult, N., Iris, L., and Lenegre, J. In “Enzymologie et Immunologie dans l’Athêrosclêrose.” ColloqueGoogle Scholar
  32. International Bordeaux. (1964a). p. 247; J.B. Bailliere, Paris, 1967.Google Scholar
  33. Scebat, L., Renais, J., Groult, N., Iris, L., and Lenegre, J. In “Enzymologie et Immunologie dans l’Athêrosclêrose.” ColloqueGoogle Scholar
  34. International Bordeaux. (1964b). p. 249; J.B. Bailliere, Paris.Google Scholar
  35. Scebat, L., Renais, J., Iris, L., Groult, N., and Lenegre, J. (1966a). Revue l’Athêrosclêr. Arteriopathies Peripheriques 8, 56.Google Scholar
  36. Scebat, L., Renais, J., Groult, N., Iris, L., and Lenegre, J. (1966b). Revue Fr, Etud. Clin. Biol. 11, 806.Google Scholar
  37. Scebat, L., Renais, J., and Groult, N. (1967a). Revue l’Athéroscier. Arteriopathies Peripheriques 9, 50.Google Scholar
  38. Scebat, L., Renais, J., Groult, N., and Lenegre, J. (1967b). In “The Reticuloendothelial System and Atherosclerosis.” (DiLuzio N. R. and Paoletti, R. eds.), p. 451. Plenum Press, New York.Google Scholar
  39. Scebat, L., Renais, J., Iris, L., Groult, N., and Lenegre, J. (1968). In “Le Róle de la Paroi Artérielle dans l’Athérogénése.” p. 425, C.N.R.S., Paris.Google Scholar
  40. Szigeti, L., Ormos, J., Jako, J., and Toszegi, A. (1960). Acta Allergol. Suppl. VII, 374.Google Scholar
  41. Szigeti, L., Piko, C., and Doman, J. (1968). In “Le Rôle de la Paroi Arteriélle dans l’Athérogénése.” p. 493. C.N.R.S., Paris.Google Scholar
  42. Thomson, J.C. (1969). Lancet 2, 1297.CrossRefGoogle Scholar
  43. Tsonev, I., Hadjiisky, P., Renais, J., and Scebat, L. (1972a). Pathol. Biol. 20, 383.PubMedGoogle Scholar
  44. Tsonev, I., Hadjiisky, P., Renais, J., and Scebat, L. (1972b). Z. Forsch.Mikrosk. Anat. 86, 177.Google Scholar
  45. Walford, R.L. (1969). “The Immunologic Theory of Aging.” Munksgaard, Copenhagen.Google Scholar
  46. Wegelius, O., Jokinen, E.J., Vonknorring, J., and Friman, C. (1970). Ann. Med. Exp. Biol. Fenn. 48, 3.Google Scholar
  47. Wegmann, R., and Fouquet, J.P. (1961). Ann. Histochim. 6, 61.Google Scholar
  48. Zemplenyi, T. (1968). In “Enzyme Chemistry of the Arterial Wall.” p. 145. Lloyd-Luke, London.Google Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • J. Renais
    • 1
  • P. Hadjiisky
    • 1
  • L. Scebat
    • 1
  1. 1.Centre de Recherches CardiologiquesHopital BoucicautParisFrance

Personalised recommendations