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Effects of Serum Lipoproteins on the Morphology, Growth, and Metabolism of Arterial Smooth Muscle Cells

  • Katti Fisher-Dzoga
  • Robert Chen
  • Robert W. Wissler
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 43)

Abstract

This paper summarizes some of the work we have been doing during the past five years to study the effects of hyperlipemia upon the growth, morphology and metabolism of arterial medial cells grown from primary explants. Although tissue culture methods have been used for over 70 years they were first introduced in the study of problems related to atherogenesis during the 1950’s. Since this time there have been many studies of both experimentally induced and naturally occurring hyperlipemia and their effects on cultured cells, either of vascular origin or, more often, of established cell-lines unrelated to vascular tissue. Work has been reported on this subject by Rutstein and associates (1964), Robertson (1967), Rothblatt (1969), Baily and Keller (1971) and others. We have chosen to concentrate our efforts on medial cells, since more and more evidence has emphasized their importance in the pathogenesis of mammalian atherosclerosis (Haust et al., 1960; Wissler, 1968; Stary and McMillan, 1970; Thomas et al., 1971).

Keywords

High Density Lipoprotein Cholesterol Ester Normal Rabbit Serum Lipoprotein Fraction Lipid Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bailey, P.J., and Keller, D. (1971). Atherosclerosis 13, 333.PubMedCrossRefGoogle Scholar
  2. Haust, M.D., More, R.H., and Movat, H.Z. (1960). Amer. J. Pathol. 37, 377.Google Scholar
  3. Havel, R.J., Howard, A.E., and Bragdon, J.M. (1955). J. Clin. Invest. 34, 1345.PubMedCrossRefGoogle Scholar
  4. Robertson, A.L. (1967). In “Lipid Metabolism and Tissue Culture Cells” (G.M. Rothblatt and D. Kritchevsky, eds.), Wistar Institute Symposium Monograph 6, pp. 115–125.Google Scholar
  5. Rothblatt, G.M. (1969). Advan. Lipid Res. 1, 135.Google Scholar
  6. Rutstein, D.D., Costelli, W.P., Sullivan, J.C., Newell, J.M., and Nickerson, R.J. (1964). New Engl. J. Med. 271, 1.PubMedCrossRefGoogle Scholar
  7. Stary, H.C., and McMillan, G.C. (1970). Arch. Pathol. 89, 173.PubMedGoogle Scholar
  8. Thomas, W.H., Florentin, R.A., Nam, S.C., Reiner, J.M., and Lee, K.T. (1971). Exp. Mol. Pathol. 15, 245.PubMedCrossRefGoogle Scholar
  9. Wissler, R.W. (1968). J. Atheroscler. Res. 8, 201.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1974

Authors and Affiliations

  • Katti Fisher-Dzoga
    • 1
  • Robert Chen
    • 1
  • Robert W. Wissler
    • 1
  1. 1.Department of PathologyUniversity of ChicagoChicagoUSA

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