Studies of Primate Arterial Smooth Muscle Cells in Relation to Atherosclerosis
Arterial smooth muscle cells play a major role in the genesis of the lesions of atherosclerosis (French, 1966; Haust and More, 1963; Jones et al., 1967; McGill and Geer, 1963; Wissler, 1967). Other cells, such as hematogenously derived macrophages, have been found within the lesions, but there is little evidence that they play a principal part in lesion development. Numerous observations of human lesions and of lesions produced in experimental animals have provided clear evidence that the lesions of atherosclerosis are fundamentally proliferative, and have suggested that they result from the migration of arterial smooth muscle cells from the media into the intima followed by their subsequent proliferation. Concomitant with or subsequent to this cell migration and proliferation, intracellular and extracellular lipids are deposited in association with formation of new extracellular connective tissue matrix constituents, including collagen, elastic fibers, and glycosaminoglycans.
KeywordsSmooth Muscle Cell High Density Lipoprotein Elastic Fiber Internal Elastic Lamina Arterial Smooth Muscle Cell
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