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Crystallography of a Metal-Containing Protein, Concanavalin A

  • Karl D. Hardman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 40)

Abstract

Concanavalin A* is a protein of the class called lectins. These proteins agglutinate or bind to the surfaces of various types of cells, specifically by interaction with carbohydrates on the surface membranes, and are of current interest in various types of cancer research. Many proteins of this class have been referred to as phytohemagglutinins or phytoagglutinins (Boyd and Shapleigh, 1954), but the term lectin has come into prominance more recently because not all of these substances are found in plants. Some have been isolated from invertebrates and lower vertebrates such as fish (Pardoe and Uhlenbruck, 1970). A short review on lectins by Sharon and Lis (1972) has recently appeared and is an excellent source for additional references.

Keywords

Polypeptide Chain Carbonyl Oxygen Subunit Structure Jack Bean Calcium Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

Con A

concanavalin A

αMeManp

α-methyl-D-mannopyranoside

αMeGlcp

α-methyl-D-glucopyranoside

βIphGlcp

β-(o-iodophenyl)-D-glucopyranoside

βIphGalp

β-(o-iodophenyl)-D-galactopyranoside

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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Karl D. Hardman
    • 1
  1. 1.Division of Biological and Medical ResearchArgonne National LaboratoryArgonneUSA

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