Abstract
It can be no great exaggeration to describe chelation as a seminal concept in modern biochemical theory and practice. Beginning with the work of Werner (A. Werner (1893), Anorg. u. Allgem. Chem., 3, 267; (1901), Ber., 34, 2584), and extending through the illuminating organic, physical-chemical, and pharmacological studies of such pioneers as Schwarzenbach, Martell, and Albert, the idea of molecular rearrangements, alterations in charge, conformational changes, etc., undergone by both metal and organic ligands as a result of their interaction to form complexes and chelate structures could not help but evoke visions of biological control, especially with respect to the action of enzymes and drugs. By now, several thousand papers dealing with chelation phenomena in living systems have appeared in the literature, and no modern textbook of biochemistry or pharmacology is without numerous examples of chelation reactions between metals such as calcium, magnesium, iron, zinc, copper, manganese, molybdenum, cobalt, or chromium, and organic metabolites ranging in complexity from glycine to coenzyme-mediated enzymes.
Work supported by the U. S. Atomic Energy Commossion
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Suggested Reading
Albert, A. (1968), Selective Toxicity, 4th ed., London: Methuen. Note particularly Chapter 9, pp. 297–352.
Brown, D. H. and MacPherson, J. (1972), J. Inorg. Nucl. Chem., 34, 1705.
Chaberek, S. and Martell, A. E. (1959), Organic Sequestering Agents, New York: John Wiley.
Davies, I. J. T. (1972), The Clinical Significance of the Essential Biological Metals, London: Heinemann.
DiStefano, V. and Neuman, W. J. (1953), J. Biol. Chem., 200, 759.
Dwyer, F. P. and Mellor, D. P. (1964), Chelating Agents and Metal Chelates, New York: Academic Press.
Korolkovas, A. (1970), Essentials of Molecular Pharmacology, New York: Wi ley-Interscience.
Martell, A. E. and Calvin, M. (1952), Chemistry of the Metal Chelate Compounds, New York: Prentice-Hall.
Morgan, G. T. and Drew, H. D. K. (1920), J. Chem. Soc. 117, 1456.
Schubert, J. (1966), Scientific American, 214, 40.
Schwarzenbach, G. (1952), Helv. Chimica Acta, 35, 2344.
Seven, M. J. and Johnson, L. A. (1960), Metal Binding in Medicine, Philadelphia: Lippincott.
Sillon, L. G. and Martell, A. E. (1964), Stability Constants of Metal-Ion Complexes, 2nd ed., London: The Chemical Society.
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© 1973 Plenum Press, New York
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Lindenbaum, A. (1973). A Survey of Naturally Occurring Chelating Ligands. In: Dhar, S.K. (eds) Metal Ions in Biological Systems. Advances in Experimental Medicine and Biology, vol 40. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3240-4_4
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DOI: https://doi.org/10.1007/978-1-4684-3240-4_4
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