A Survey of Naturally Occurring Chelating Ligands
It can be no great exaggeration to describe chelation as a seminal concept in modern biochemical theory and practice. Beginning with the work of Werner (A. Werner (1893), Anorg. u. Allgem. Chem., 3, 267; (1901), Ber., 34, 2584), and extending through the illuminating organic, physical-chemical, and pharmacological studies of such pioneers as Schwarzenbach, Martell, and Albert, the idea of molecular rearrangements, alterations in charge, conformational changes, etc., undergone by both metal and organic ligands as a result of their interaction to form complexes and chelate structures could not help but evoke visions of biological control, especially with respect to the action of enzymes and drugs. By now, several thousand papers dealing with chelation phenomena in living systems have appeared in the literature, and no modern textbook of biochemistry or pharmacology is without numerous examples of chelation reactions between metals such as calcium, magnesium, iron, zinc, copper, manganese, molybdenum, cobalt, or chromium, and organic metabolites ranging in complexity from glycine to coenzyme-mediated enzymes.
KeywordsKOJIC Acid Modern Textbook Chelation Reaction Chelation Process Seminal Concept
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