Cobalt Substituted Zinc Metalloenzymes

  • Bert L. Vallee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 40)


It has taken a long time, indeed, for biochemical research on metals to become respectable. Substantial experimental difficulties have beset the field for a long time and overenthusiastic claims, at times based on uncertain facts, were not altogether reassuring to the rank and file of interested biochemists.


Electron Paramagnetic Resonance Circular Dichroic Spectrum Zinc Atom Cobalt Atom Metal Loenzymes 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Behnke, W. D. and Vallee, B. L. (1972), Proc. Nat. Acad. Sci. U. S., 69, 2442.CrossRefGoogle Scholar
  2. Drum, D. E., Harrison, J. H., IV, Li, T.-K., Bethune, J. L., and Vallee, B. L. (1967), Proc. Nat. Acad. Sci. U. S., 57, 1434.CrossRefGoogle Scholar
  3. Drum, D. E. and Vallee, B. L. (1970), Biochem. Biophys. Res. Comm., 41, 33.PubMedCrossRefGoogle Scholar
  4. Kasper, C. B. (1968), J. Biol. Chem., 243, 3218.PubMedGoogle Scholar
  5. Latt, S. A. and Vallee, B. L. (1971), Biochemistry, 10, 4263.PubMedCrossRefGoogle Scholar
  6. Lindskog, S. and Ehrenberg, A. (1967), J. Mol. Biol., 24, 133.CrossRefGoogle Scholar
  7. Lindskog, S. and Nyman, P. O. (1964), Biochem. Biophys. Acta, 85, 462.PubMedGoogle Scholar
  8. Simpson, R. T. and Vallee, B. L. (1968), Biochemistry, 7, 4343.PubMedCrossRefGoogle Scholar
  9. Vallee, B. L. and Latt, S. A. (1970), Structure-Function Relationships of Proteolytic Enzymes (P. Desnuelle, H. Neurath, and M. Ottesen, eds.), Copenhagen: Munksgaard, p. 144.Google Scholar
  10. Vallee, B. L. and Riordan, J. F. (1969), Ann. Rev. Biochem., 38, 539.CrossRefGoogle Scholar
  11. Vallee, B. L. and Wacker, W. E. C. (1970), Metalloproteins, The Proteins, 2nd ed. (H. Neurath, ed.) 5, New York: Academic Press.Google Scholar
  12. Vallee, B. L. and Williams, R. J. P. (1968), Proc. Nat. Acad. Sci. U. S., 59, 498.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Bert L. Vallee
    • 1
    • 2
  1. 1.Biophysics Research Laboratory, Department of Biological ChemistryHarvard Medical SchoolBostonUSA
  2. 2.Division of Medical BiologyPeter Bent Brigham HospitalBostonUSA

Personalised recommendations