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Hormone-Receptor Interactions with the Genome of Eucaryotic Target Cells

  • Bert W. O’Malley
  • William T. Schrader
  • Thomas C. Spelsberg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 36)

Abstract

Progesterone induces de novo synthesis of the specific protein avidin in estrogen-primed chick oviducts. The specificity and kinetics of induction of this protein has been the subject of a series of past publications from our laboratory (1–6). We have previously shown that progesterone causes major quantitative and qualitative alterations in oviduct gene transcription. Induction of avidin was blocked by actinomycin D. Changes in rapidly-labeled nuclear RNA and nuclear RNA polymerase activities supported a transcriptional effect of the hormone (4–7).

Keywords

Scatchard Plot Receptor Component Chromatin Binding Cytosol Receptor Corticosteroid Binding Globulin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Bert W. O’Malley
    • 1
  • William T. Schrader
    • 1
  • Thomas C. Spelsberg
    • 1
  1. 1.Departments of Obstetrics-Gynecology, Biochemistry and MedicineVanderbilt University School of Medicine NashvilleUSA

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