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Estrogen Binding in the Rat and Human

  • P. K. Siiteri
  • B. E. Schwarz
  • I. Moriyama
  • R. Ashby
  • D. Linkie
  • P. C. MacDonald
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 36)

Abstract

The interaction of estrogens with human target tissues has received scant attention as compared with other species. Early reports demonstrated that radioactive estradiol is concentrated by the human uterus in vivo (1), and is specifically bound in cytosol prepared from human endometrium (2,3,M. However, a specific cytoplasmic 8S estrogen receptor similar to that found in the rat and other species has been demonstrated in human tissues only recently by Siiteri et al. (5). The possible role of estrone in estrogen action is uncertain although several reports have shown its formation in human uterine tissue (6,7). Our interest in this problem arose from studies which demonstrated that the estrogen target organs of the human postmeno-pausal female are exposed principally to estrone rather than estradiol (8,9)• Together with similar observations made in a variety of clinical conditions which are associated with a high incidence of endometrial carcinoma, such as the polycystic ovarian syndrome, severe obesity, liver disease, and a variety of ovarian tumors, these findings indicate that exclusive production of estrone is a common endocrinologic feature of this form of neoplasia. The possibility of a causal role for estrone in the development of endometrial cancer must therefore be considered. For these reasons investigations of the interaction of the human uterine estrogen receptor system with both estradiol and estrone have been carried out.

Keywords

Human Serum Albumin Nuclear Extract Receptor Complex Solid Circle Human Endometrium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • P. K. Siiteri
    • 1
  • B. E. Schwarz
    • 1
  • I. Moriyama
    • 1
  • R. Ashby
    • 1
  • D. Linkie
    • 1
  • P. C. MacDonald
    • 1
  1. 1.Departments of Obstetrics and Gynecology and BiochemistryThe University of Texas Southwestern Medical SchoolDallasUSA

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