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Estrogen Receptor Transformation and Nuclear RNA Synthesis

  • Elwood V. Jensen
  • Suresh Mohla
  • Peter I. Brecher
  • Eugene R. DeSombre
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 36)

Abstract

Studies from many laboratories (l) have demonstrated that the characteristic affinity of estrogen-responsive tissues for the hormone, both in vivo and in vitro, results from their content of specific estrogen-binding proteins called estrogen receptors or estrophiles. The interaction of estradiol with target tissues, such as uterus, takes place by a sequential mechanism in which the hormone first combines with an extranuclear receptor protein to form a complex which, by a temperature-dependent process, is translocated to the nucleus where most of the incorporated steroid becomes localized (Fig. 1).

Keywords

Soluble Enzyme Liver Nucleus Cytosol Complex Bovine Plasma Albumin Uterine Cytosol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Elwood V. Jensen
    • 1
  • Suresh Mohla
    • 1
  • Peter I. Brecher
    • 1
  • Eugene R. DeSombre
    • 1
  1. 1.The Ben May Laboratory for Cancer ResearchThe University of ChicagoChicagoUSA

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