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Nuclear Receptor · Estrogen Complexes of Rat Uteri:

Concentration-Time-Response Parameters

  • Chapter
Receptors for Reproductive Hormones

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 36))

Abstract

Estrogen sensitive tissues contain macromolecules called receptors, R, that bind estrogen, E, in a stereospecific manner. This binding interaction is generally considered to be a prerequisite for estrogen-induced responses (1,2,3). The formation of the receptor estrogen complex, R·E, occurs in the cytoplasm of estrogen sensitive cells, and this complex is translocated to the nucleus where it is probably bound to acceptor sites on the chromatin (1,2, 4). The interaction of R·E with acceptor sites in the nucleus is considered to be important in the stimulation of RNA synthesis which ultimately results in estrogen-induced responses (4–8). Most of these conclusions have arisen from experiments with uterine tissue in vitro or under cell free conditions. Little is known about the relationship between the receptor·estradiol interaction and estrogen-induced responses in vivo. The purpose of the following experiments is to describe the relationships between the receptor estrogen interaction and estrogenic responses under physiologic circumstances.

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Author information

Authors and Affiliations

  1. Department of Biological Sciences, Purdue University, Lafayette, Indiana, 47907, USA

    J. H. Clark, J. N. Anderson & E. J. Peck Jr.

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  1. J. H. Clark
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  2. J. N. Anderson
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  3. E. J. Peck Jr.
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Editor information

Editors and Affiliations

  1. Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA

    Bert W. O’Malley M.D.  & Anthony R. Means Ph.D.  & 

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© 1973 Plenum Press, New York

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Clark, J.H., Anderson, J.N., Peck, E.J. (1973). Nuclear Receptor · Estrogen Complexes of Rat Uteri:. In: O’Malley, B.W., Means, A.R. (eds) Receptors for Reproductive Hormones. Advances in Experimental Medicine and Biology, vol 36. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3237-4_2

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  • DOI: https://doi.org/10.1007/978-1-4684-3237-4_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3239-8

  • Online ISBN: 978-1-4684-3237-4

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