Biochemical Changes in Mitochondria as a Mechanism in Metabolic Tolerance to Ethanol

  • Arun K. Rawat
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 35)


Ethanol when administered to animals or humans produces a variety of biochemical and pharmacological effects. Some of these effects are due to ethanol per se and others due to its metabolites. The relative significance of these effects depends on the quantity of ethanol administered. Research done over the last 10 years has furnished considerable knowledge regarding the metabolism of ethanol and the biochemical and pharmacological effects of short-term ethanol consumption, as reviewed elsewhere (Rawat, 1969). Although, in the past, effects of excess long-term ethanol consumptions have been investigated on the morphological and histological changes in various organs of the body; much attention to biochemical changes has not been given. Advances in structural techniques like electron microscopy have mainly contributed to the understanding of ultrastructure changes induced by ethanol (Popper and Schaffner, 1970).


Alcohol Dehydrogenase Liver Mitochondrion Nicotinamide Adenine Dinucleotide Chronic Ethanol Ethanol Oxidation 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Arun K. Rawat
    • 1
  1. 1.Downstate Medical CenterState University of New YorkNew YorkUSA

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