Abstract
Ethyl alcohol (ethanol), which is, a nutrient, a tranquilizer, an euphoristic beverage, is also a toxic responsible of so much human degradation, a social plague increasing the death rate among the adult population (Fig. 1). Very curiously, its metabolic effects, which are certainly in relation with its aforementioned properties, do not draw the scientific attention they deserve, althrough the consumption of ethanol is a widespread fact.
In this paper, “alcohol”, “ethyl alcohol” and “ethanol are synonymous”.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Bibliography
Atkinson, D.E. Regulation of enzyme activity. Ann. Rev. Biochem., 35:85–124, 1966.
Baron, P., Griffaton, G. & Lowy, R. Etude comparée des perturbations métaboliques provoquées dans le foie du rat par administration d’éthanol ou d’autres composés. I) Cas d’une injection i.p. d’éthanol. Fd. Cosmet. Toxicol., 6:729–736, 1968.
Baron, P., Griffaton, G. & Lowy, R. Effets d’une injection i.p. d’éthanol sur le métabolisme hépatique du rat. Fd. Cosmet. Toxical., 7:309–316, 1969.
Baron, P., Griffaton, G. & Lowy, R. Effets d’une injection i.p. simultanée de fructose et d’éthanol sur le métabolisme hépatique du rat. Arch. Sci. Physiol., 24:331–336, 1970.
Baron, P., Griffaton, G. & Lowy, R. Effets d’une administration simultanée de pyruvate et d’éthanol sur le métabolisme hépatique du rat. Arch. Intern. Physiol. Biochem., (In Press).
Borst, P. (1961), quoted by Thieden, Lundquist & Grunnet. Proc. 5th Intern. Congr. Biochem., 2:233, 1971.
Decloitre, F. & Lowy, R. Modifications des constituants phosphorés hépatiques et pancréatiques du rat par injection d’éthanol. Compt. Rend. Soc. Biol., 157:46–51, 1963.
Forsander, O.A. Extrahepatic oxidation of alcohol and alcohol metabolites. In G.A. Martini et Ch. Bode, Metabolic changes induced by alcohol. Springer-Verlag, Berlin, pp. 14–22, 1971.
Forsander, O.A., Mäenpää, P.H. and Salaspuro, M.P. Influence of ethanol on the lactate/pyruvate and α-hydroxybutyrate/acetoacetate ratios in rat liver experiments* Acta Chenu Scand., 19:1770–1771, 1965.
Forsander, O.A. and Raiha, N.C.R. Metabolites produced in the liver during alcohol oxidation. J. Biol. Chem., 235:34–36, 1960.
Greville, G.D. Factors affecting the utilization of substrates by mitochondria. In Regulation of metabolic processes by mitochondria. Elsevier Publ. Co., Amsterdam, 1965.
Griffaton, G. & Lowy, R. Oxydation de l’éthanol par un systeme peroxydasique dans des homogénats de foie provenant de rats ayant recu une injection i.p. d’éthanol. Compt. Rend. Soc. Biol., 156:1982–1987, 1962.
Griffaton, G., Baron, P. & Lowy, R. Effets d’une administration aiguë d’éthanol et de fructose sur les teneurs en nucléotides adényliques du foie de rat. Arch. Intern. Physiol. Biochem., 79:75–85, 1971.
Griffaton, G., Lowy, R. & Baron, P. Effets d’un sel de l’acide α-cétoglutarique sur les perturbations métaboliques provoquées par l’éthanol chez le rat. (To be published).
Goodwin, T.W. Metabolic roles of citrate. Academic Press, London — New York, 1968.
Hassinen, I. Hydrogen transfer into mitochondria in the metabolism of ethanol. I. Oxidation of extramitochondrial reduced NAD by mitochondria. Ann. Med. Exp. Biol. Fenn., 45:35, 1967.
Keilin, D. & Hartree, E.F. Coupled oxidation of alcohol. Proc. Roy. Soc, B 119:141, 1936.
Kinard, F.W., Nelson, G.H. & Hay, M.G. (1956) Proc. Soc. Exp. Biol. Med., 92:772. Quoted by Nelson 1958.
Kinard, F.W., Aull, J. & Hay, M.G. Quart. J. Stud. Alc, 18:343. Quoted by Nelson 1958.
Laporte, J.C. unpublished results, 1971.
Lehninger, A.L., Sudduth, H.C. & Wise, J.B. D-β-hydroxybutiric dehydrogenase of mitochondria. J. Biol. Chem., 235:2450–2455, 1960.
Lieber, Ch. S. & De Carli, L.M. Ethanol oxidation by hepatic microsomes: Adaptive increase after ethanol feeding. Science, 162:917–918, 1968.
Lieber, Ch. S. Effect of ethanol on the activity of microsomal enzymes. In G.A. Martini & Ch. Bode, Metabolic changes induced by alcohol, Springer-Verlag, Berlin, pp. 85–92, 1971.
Lowy, R,, Baron, P. & Griffaton, G. Perturbations provoquées par l’éthanol administré par voie i.p. dans le métabolisme cellulaire hépatique du rat. Rev. Alcool., 16:127–140, 1970.
Lowy, R. & Griffaton, G. Recherches de physiologie cellulaire sur la toxicité de l’alcool éthylique. Fd. Cosmet. Toxicol., 3:749–767, 1965.
Lundquist, F., Thieden, H. & Grunnet, N. Ethanol as an energy-producing substrate in theliver. In G.A. Martini & Ch. Bode, Metabolic changes induced by alcohol, Springer-Verlag, Berlin, pp. 108–114, 1971.
Nelson, G.H. Ethanol protection against the catalase depressing effect on 3-amino-1,2,4 triazole (AT). Science, 127:520–521, 1958.
Nordmann, R. & Nordmann, J. Recherches sur la régulation du métabolisme glucidique in vivo. II. Action de l’éthanol. Bull. Soc. Chim. Biol., 51:791–798, 1969.
Orme-Johnson, W.H. & Ziegler, D.M. Biochem. Biophys. Res. Communs. 21:78. Quoted by Lundquist, Thieden & Grunnet, 1971.
Thieden, H.I.D. and Lundquist, F. The influence of fructose and its metabolites on ethanol metabolism in vitro. Biochem. J., 102:177–180, 1967.
Tremolieres, J. & Carre. L. Mise en évidence de systèmes peroxydasiques oxydant l’alcool chez l’alcoolique. C.R. Acad. Sci., 251-2785, 1960.
Tremolieres, J. & Carre, L. Production d’activités peroxydasiques dans le plasma de l’alcoolique, par ingestion d’éthanol. Compt. Rend. Soc. Biol., 155:1022–1025, 1961.
Tremolieres, J. & Carre, L. Mise en évidence d’un système peroxdasique oxydant l’éthanol par injection d’éthanol au rat, a des doses toxiques. Compt. Rend. Soc. Biol., 156:458–461, 1962.
Tremolieres, J., Carre, L., Scheggia, E., Delcroix, P. & Potet, F. Pancréatites alcooliques. Etude des bases de la thérapeutique Rev. Alcool., 9:171–186, 1963a.
Tremolieres, J., Carre, L., Scheggia, E., Potet, F. & Martin, E. Pancréatites necrosantes et hémorragiques par administration d’éthanol à doses toxiques et répétées au rat. Compt. Rend. Soc. Biol., 157:1189–1190, 1963b.
Tremolieres, J. & Lowy, R. Physiology of ethanol oxidation at normal and toxic levels. International Encyclopedia of Pharmacology and Therapeutics, Vol. XX:Alcohol and derivatives. Edited by J. Tremolieres-Pergamon Press, Oxford pp. 139–160, 1970.
Ugarte, G., Pereda, T., Pino, M.E. & Iturriaga, H. Dégradation de l’alcool dans l’alcoolisme chronique. Internationales Symposion: Alkohol und Leber, Freiburg i. Br., 2–4 Oct. 1970.
Videla, L. and Israel, Y. (1971) Quoted by Ugarte et al., 1970.
Westerfeld, W.W. & Schulman, M.P. Metabolism and caloric value of alcohol. J. Amer. Med. Assoc., 170:197–203, 1959.
Whereat, A.F., Orishimo, M.W., Nelson, J. and Phillips, S.J. The location of different synthetic systems for fatty acids in inner and outer mitochondrial membranes from rabbit heart. J. Biol. Chem., 244:6498–6506, 1969.
Williamson, D.H., Lund, P. & Krebs, H.A. The redox state of free nicotinamide adenine dinucleotides in the cytoplasm and mitochondria of rat liver. Biochem. J., 103:514–527, 1967.
Williamson, J.R., Scholz, R., Browning, E.T., Thurman, R.G. & Fukami, M.H. Metabolic effects of ethanol in perfused rat liver. J. Biol. Chem., 244:5044–5054, 1969.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1973 Plenum Press, New York
About this chapter
Cite this chapter
Tremolieres, J., Lowy, R., Griffaton, G. (1973). The Metabolic Basis of Ethanol Toxicity. In: Gross, M.M. (eds) Alcohol Intoxication and Withdrawal I. Advances in Experimental Medicine and Biology, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3234-3_8
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3234-3_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3236-7
Online ISBN: 978-1-4684-3234-3
eBook Packages: Springer Book Archive