Effects of Ethanol on Liver Metabolism

  • Edward Majchrowicz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 35)


Changes in the liver level of lipids and fatty acids occur as results of either acute or chronic administration of ethanol, but the mechanism of such changes is not completely known. Theoretically, there are several possible mechanisms which may explain this process: e.g., ethanol may stimulate the synthesis of hepatic triglycerides from peripheral and administered fatty acids and glycerol (Mallov, 1957; Di Luzio, 1958; Horning et al., 1960; Nikkila & Ojala, 1963; Scheig & Isselbacher, 1965; Kessler & Mishkin, 1966) or it may stimulate fatty acid synthesis in the liver as suggested by Lieber and Schmidt (1961; Lieber et al., 1959). The accumulation of lipids may also be produced by suppressing the oxidation of fatty acids (Majchrowicz & Quastel, 1959, 1961, 1963; Reboucas & Isselbacher, 1961; Wooles, 1966; Fex & Olivecrona, 1968) in the liver or by suppression of lipid release from the liver (Schapiro et al., 1964; Bezman-Tarcher, 1966).


Fatty Acid Synthesis Respiratory Quotient Citric Acid Cycle Liver Slice Liver Metabolism 
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  1. Abraham, S., P. Hirsch and I. Chaikoff, J. Biol. Chem. 211:31, 1954.Google Scholar
  2. Abraham, S., K. J. Matthes and I. L. Chaikoff, Biochem. Biophys. Acta. 36:556, 1959.CrossRefGoogle Scholar
  3. Alexander, N. M., Scheig, R. and Klatskin, G., J. Lip. Res. 7:197, 1966.Google Scholar
  4. Ammon, H.P.T., Naunyn-Schmiedebergs Arch. Exp. Path. Pharmak. 251:114, 1965.CrossRefGoogle Scholar
  5. Ammon, H.P.T. and C. J. Estler, Klin. Wschr. 44:651, 1966.Google Scholar
  6. Ammon, H.P.T., C. J. Estler and F. Heim, Arch. int. Pharmacodyn. 159:258, 1966.Google Scholar
  7. Ammon, H.P.T., F. Heim, C. J. Estler, G. Fickeis and M. Wagner, Biochem. Pharmacol. 16:1533, 1967.CrossRefGoogle Scholar
  8. Ariyoshi, T., E. Takabatake and H. Remmer, Life. Sci. 9, Part II, 361, 1970.CrossRefGoogle Scholar
  9. Barboriak, J. J., Life Sci. 5:237, 1966.CrossRefGoogle Scholar
  10. Bezman-Tarcher, A., P. J. Nestel, J. M. Felts and R. J. Havel, J. Lip. Res. 7:248, 1966.Google Scholar
  11. Bornstein, A. and A. Loewy, Biochem. Z. 191:271, 1927.Google Scholar
  12. Brady, R. O., R. M. Bradley and E. G. Trams, J. Biol. Chem. 235:3093, 1960.Google Scholar
  13. Brodie, B. B., W. M. Butler, Jr., Marjorie C. Horning, R. P. Maickel and Harriet M. Maling, Am. J. Clin. Nutr. 9:432, 1961.Google Scholar
  14. Brodie, B. B. and R. P. Maickel, Ann. N.Y. Acad. Sci. 104:1049, 1963.Google Scholar
  15. Brown, E. A., J. M. Hunter and Harriet M. Maling, Proc. Soc. Exper. Biol. Med. 122:1079, 1966.Google Scholar
  16. Burton, R. M. and E. R. Stadtman, J. Biol. Chem. 202:873, 1953.Google Scholar
  17. Di Luzio, N. R., Am. J. Physiol. 194:453, 1958.Google Scholar
  18. Di Luzio, N. R., Life Sci. 4:1373, 1965.CrossRefGoogle Scholar
  19. Farber, E., K. H. Shull, S. Villa-Trevino, B. Lombardi and M. Thomas, Nature; Lond. 203:34, 1964.CrossRefGoogle Scholar
  20. Fex, G. and Th. Olivecrona, Acta. physiol. scand. 75:78, 1968.CrossRefGoogle Scholar
  21. Forsander, O. A., Biochem. J. 98:244, 1966.Google Scholar
  22. Forsander, O. A. and J. J. Himberg, Metabolism 18:776, 1969.CrossRefGoogle Scholar
  23. Forsander, O. A. and K. O. Lindros, Acta Chem. Scand. 21:2568, 1967.CrossRefGoogle Scholar
  24. Forsander, O. A., N. Raiha, M. Salaspuro and P. Maenpaa, Biochem. J. 94:259, 1965.Google Scholar
  25. Freinkel, N., R. A. Arky, D. L. Singer, A. K. Cohen, S. J. Bleicher, J. B. Anderson, C. K. Silbert and A. E. Foster, Diabetes 14:350, 1965.Google Scholar
  26. French, S. W., Proc. Soc. Exp. Biol. Med. 121:681, 1966.Google Scholar
  27. Fritz, I. B., Physiol. Rev. 41:52, 1961.Google Scholar
  28. Gajdos, A., M. Gajdos-Torok, A. Palma-Carlos and L. Palma-Carlos, C. R. Soc. Biol. (Paris) 159:2185, 1965.Google Scholar
  29. Higgins, H. L., J. Pharmacol. 9:441, 1917.Google Scholar
  30. Horning, Marjorie G., E. A. Williams, Harriet M. Maling and B. B. Brodie, Biochem. Biophys. Res. Comm. 3:635, 1960.CrossRefGoogle Scholar
  31. Horning, Marjorie G., M. Wakabayashi and Harriet M. Maling, Proc. 1st Internat* Pharmacol. Meet., p. 13, The MacMillan Co., 1963.Google Scholar
  32. Hyams, D. E. and K. J. Isselbacher, Nature 204:1196, 1964.CrossRefGoogle Scholar
  33. Isselbacher, K. J. and N. J. Greenberger, New Engl. J. Med. 270:351, 402, 1964.CrossRefGoogle Scholar
  34. Jones, D. P., M. S. Losowski, C. S. Davidson and C. S. Lieber, J. Clin. Investigation 42:945, 1963.CrossRefGoogle Scholar
  35. Kessler, J. I. and S. Yalovsky-Mishkin, J. Lip. Res. 7:772, 1966.Google Scholar
  36. Klainer, L. M., Y. M. Chi, S. L. Freidberg, T. W. Rail and E. W. Sutherland, J. Biol. Chem. 237:1239, 1962.Google Scholar
  37. Krebs, H. A., R. A. Friedland, R. Hems and Marion Stubs, Biochem. J. 112:117, 1969.Google Scholar
  38. Langdon, R. G., J. Amer. Chem. Soc. 77:5190, 1955.CrossRefGoogle Scholar
  39. Lehninger, A. L., The Mitochondria, New York: W. A. Benjamin, Inc., p. 90, 1964.Google Scholar
  40. Leloir, L. F. and J. M. Munoz, Biochem. J. 32:299, 1938.Google Scholar
  41. Lieber, C. S., Leonore M. DeCarli and R. Schmid, Biochem. Biophys. Res. Comm. 1:302, 1959.CrossRefGoogle Scholar
  42. Lieber, C. S. and R. Schmid, J. Clin. Invest. 40:394, 1961.CrossRefGoogle Scholar
  43. Lieber, C. S. and C. S. Davidson, Am. J. Med. 33:319, 1962.CrossRefGoogle Scholar
  44. Lieber, C. S. Progress in Liver Diseases, Popper, H. and F. Schaffner (eds), Grune and Stratton, New York and London, 1965, Chapter XI, p. 134.Google Scholar
  45. Lundquist, F., Nature 193:579, 1962.CrossRefGoogle Scholar
  46. Lundquist, F., U. Fugmann, H. Rasmussen, and T. Svendsen, Biochem. J. 84:281, 1962.Google Scholar
  47. Lundquist, F., N. Tygstrup, K. Winkler, K. Mellemgaard and S. Munck-Petersen, J. Clin. Invest. 41:955, 1962a.CrossRefGoogle Scholar
  48. Maickel, R., H. Sussman, K. Yamada and B.B. Brodie, Life Sci. 3:310, 1963.Google Scholar
  49. Mallov, S. and J. L. Bloch, Am. J. Physiol. 184:29, 1956.Google Scholar
  50. Mallov, S., Am. J. Physiol. 189:428, 1957.Google Scholar
  51. Majchrowicz, E. and J. H. Quastel, reported by J. H. Quastel, Quart. J. Stud. Alc. 20:428, 1959.Google Scholar
  52. Majchrowicz, E. and J. H. Quastel, Canad. J. Biochem. Physiol. 39:1895, 1961.CrossRefGoogle Scholar
  53. Majchrowicz, E. and J. H. Quastel, Canad. J. Biochem. Physiol. 41:793, 1963.CrossRefGoogle Scholar
  54. Majchrowicz, E., Proc. Soc. Exper. Biol. Med. 115:615, 1964.Google Scholar
  55. Majchrowicz, E., Canad. J. Biochem. 43:1041, 1965.CrossRefGoogle Scholar
  56. Majchrowicz, E., Fifth International Congress on Pharmacology, San Francisco, 1972.Google Scholar
  57. Mattie, H., Acta Physiol. Pharmacol. Neerl. 12:1, 1963.Google Scholar
  58. Nikkila, E. A. and Karina Ojala, Proc. Soc. Exper. Biol. Med. 113:814, 1963.Google Scholar
  59. Rawat, A. K., Europ. J. Biochem. 6:585, 1968.CrossRefGoogle Scholar
  60. Rizack, M. A., J. Biol. Chem. 239:392, 1964.Google Scholar
  61. Reboucas, G. and K. J. Isselbacher, J. Clin. Invest. 40:1355, 1961.CrossRefGoogle Scholar
  62. Rothschild, M. A., M. Oratz, J. Mongelli and S. S. Schreiber, J. Clin. Invest. 50, 1812, 1971.CrossRefGoogle Scholar
  63. Rubin, E., Diane S. Beattie and C. S. Lieber, Lab. Invest. 23: 620, 1970.Google Scholar
  64. Sardesai, V. M. and J. M. Orten, J. Nutr., 96:241, 1968.Google Scholar
  65. Schapiro, R. H., Gladys D. Drummey, Y. Shimizu and K. J. Isselbacher, J. Clin. Invest. 43:1338, 1964.CrossRefGoogle Scholar
  66. Scheig, R. and K. J. Isselbacher, J. Lip. Res. 6:269, 1965.Google Scholar
  67. Siekevitz, P., J. Biol. Chem., 195:549, 1952.Google Scholar
  68. Siperstein, M. D. and V. Fagan, J. Clin. Invest. 37:188, 1958.Google Scholar
  69. Slater, T. F., Barbara C. Sawyer and Ursula D. Strauli, Biochem. J. 93:267, 1964.Google Scholar
  70. Smith, Marion E. and H. W. Newman, J. Biol. Chem. 234:1544, 1959.Google Scholar
  71. Sutherland, E. W., I. Oye and R. W. Butcher, Advances in Hormone Research 21:623, 1965.Google Scholar
  72. Tewari, S. and E. P. Noble, Brain Research 26:469, 1971.Google Scholar
  73. Umbreit, W. W., R. H. Burris and J. F. Stauffer, Manometric Techniques, Burgess Publishing Co., Minneapolis, Minn., 1957.Google Scholar
  74. Vaughan, Martha, J. Biol. Chem. 235:3049, 1960.Google Scholar
  75. Vaughan, Martha and D. Steinberg, J. Lipid Res. 4:193, 1963.Google Scholar
  76. Walker, Jennifer E.G. and Ellen R. Gordon, Biochem. J. 119:511, 1970.Google Scholar
  77. Wakil, S. J., D. E. Green, S. Mil and H. R. Mahler, J. Bio Chem. 207:631, 1954.Google Scholar
  78. Wallgren, H., Biochem. Pharmacol. 6:195, 1961.CrossRefGoogle Scholar
  79. Warembourg, H., G. Biserte, J. Jaillard, G. Sezille and P. Scherperseel, Rev. Europ. Etudes Clin. et Biol. 15:649, 1970.Google Scholar
  80. Westerfeld, W. W., Texas Rep. Biol. & Med., 13:559, 1955.Google Scholar
  81. Westerfeld, W. W., Am. J. Clin. Nutr. 9:426, 1961.Google Scholar
  82. Williamson, J. R., R. Scholtz, E. T. Browning, R. G. Thurman and M. H. Fukami, J. Biol. Chem 244:5044, 1959.Google Scholar
  83. Wooles, W. R., Life Sci. 5:267, 1966.CrossRefGoogle Scholar
  84. Zakim, P., Life Sci. 4:209, 1965.CrossRefGoogle Scholar
  85. Zakim, D., Arch. Biochem. Biophys. 111:253, 1965a.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Edward Majchrowicz
    • 1
  1. 1.Biochemistry Program, Laboratory of Alcohol ResearchNational Institute on Alcohol Abuse and Alcoholism N.I.M.H.USA

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