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Effects of Ethanol on Liver Metabolism

  • Edward Majchrowicz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 35)

Abstract

Changes in the liver level of lipids and fatty acids occur as results of either acute or chronic administration of ethanol, but the mechanism of such changes is not completely known. Theoretically, there are several possible mechanisms which may explain this process: e.g., ethanol may stimulate the synthesis of hepatic triglycerides from peripheral and administered fatty acids and glycerol (Mallov, 1957; Di Luzio, 1958; Horning et al., 1960; Nikkila & Ojala, 1963; Scheig & Isselbacher, 1965; Kessler & Mishkin, 1966) or it may stimulate fatty acid synthesis in the liver as suggested by Lieber and Schmidt (1961; Lieber et al., 1959). The accumulation of lipids may also be produced by suppressing the oxidation of fatty acids (Majchrowicz & Quastel, 1959, 1961, 1963; Reboucas & Isselbacher, 1961; Wooles, 1966; Fex & Olivecrona, 1968) in the liver or by suppression of lipid release from the liver (Schapiro et al., 1964; Bezman-Tarcher, 1966).

Keywords

Fatty Acid Synthesis Respiratory Quotient Citric Acid Cycle Liver Slice Liver Metabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Edward Majchrowicz
    • 1
  1. 1.Biochemistry Program, Laboratory of Alcohol ResearchNational Institute on Alcohol Abuse and Alcoholism N.I.M.H.USA

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