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A Role for Tetrahydroisoquinoline Alkaloids as False Adrenergic Neurotransmitters in Alcoholism

  • Gerald Cohen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 35)

Abstract

The plant alkaloids comprise a broad grouping of compounds, many of which exhibit drug action in man (Robinson, 1968). A subclassification is the tetrahydroisoquinoline (TIQ) group, which contains compounds that are related structurally to the catecholamines, viz. dopamine (DA), norepinephrine (NE) and epinephrine (E). The main thesis of this paper is that a group of TIQ alkaloids can be biosynthesized in people during alcohol intake, and that these substances can then function as false adrenergic transmitters (Cohen and Collins, 1970). By interfering with adrenergic mechanisms in the brain and in the periphery, biosynthesized TIQ alkaloids may be capable of altering mood and behavior. In this way, they may play a role during alcohol intoxication and in post-intoxication states.

Keywords

Nerve Terminal Pineal Gland Adrenal Medulla Nerve Plexus Isoquinoline Alkaloid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Axelröd, J., 1970. Noradrenaline: Fate and control of its Biosynthesis, Science 173: 598.CrossRefGoogle Scholar
  2. Brezenoff, H.E. and G. Cohen, 1973, Hypothermia evoked by a dopamine-derived tetrahydroisoquinoline alkaloid, Fed. Proc. (In press).Google Scholar
  3. Cohen, G., 1971a, Reactions of catecholamines with acetaldehyde to form tetrahydroisoquinoline alkaloids, in: Biologic Aspects of Alcoholism, eds. M.K. Roach, W.M. McIsaac and P.J. Creaven (Univ. of Texas Press, Austin), p. 267.Google Scholar
  4. Cohen, G., 1971b, Tetrahydroisoquinoline alkaloids in the adrenal medulla after perfusion with “blood concentrations” of-14C-acetaldehyde, Biochem. Pharmacol. 20, 1757.CrossRefGoogle Scholar
  5. Cohen, G. and R.E. Barrett, 1969. Fluorescence microscopy of catecholamine-derived tetrahydroisoquinoline alkaloids formed during methanol intoxication, Fed. Proc. 28: 288.Google Scholar
  6. Cohen, G. and M. Collins, 1970. Alkaloids from catecholamines in adrenal tissue: Possible role in alcoholism, Science 167: 1749.CrossRefGoogle Scholar
  7. Cohen, G., C. Mytilineou and R. Barrett, 1972. 6,7-Dihydroxytetrahydroisoquinoline: Uptake and storage by peripheral sympathetic nerve of the rat, Science 175: 1269.CrossRefGoogle Scholar
  8. Collins, M. and G. Cohen, 1970. Isoquinoline alkaloid biosynthesis from adrenal catecholamines during 14C-methyl alcohol metabolism in rats, Fed. Proc. 29: 608.Google Scholar
  9. Cooper, J.R. and M.M. Kini, 1962. Biochemical aspects of methanol poisoning, Biochem. Pharmacol. 11: 405.CrossRefGoogle Scholar
  10. Corrodi, H. and G. Jonsson, 1967. The formaldehyde fluorescence method for the histochemical demonstration of biogenic monoamines: A review on the methodology, J. Histochem. Cytochem. 15: 65.CrossRefGoogle Scholar
  11. Douglas, W.W., 1968. Stimulus-secretion coupling: The concept and clues from chromaffin and other cells, Brit. J. Pharmacol. 34: 451.Google Scholar
  12. Greenberg, R.S. and G. Cohen, 1972. Tetrahydroisoquinolines and the catecholamine-binding granules of the adrenal medulla, Eur. J. Pharmacol. 18: 291.CrossRefGoogle Scholar
  13. Greenberg, R.S. and G. Cohen, 1973. Tetrahydroisoquinoline alkaloids: Stimulated secretion from the adrenal medulla, J. Pharmacol. Exp. Ther. 184: 119.Google Scholar
  14. Heikkila, R.E., G. Cohen and D. Dembiec, 1971. Tetrahydroisoquinoline alkaloids: Uptake by rat brain synaptosomes and inhibition of catecholamine uptake, J. Pharmacol. Exp. Ther. 179: 250.Google Scholar
  15. Hökfelt, T., 1970, Electron microscopic studies on peripheral and central monoamine neurons, in: Aspects of Neuro-endocrinology, eds. W. Bargmann and B. Scharrer (Springer, New York), p. 79.Google Scholar
  16. Locke, S., D. Dembiec and G. Cohen, 1973, In vivo inhibition of neuronal uptake of a dopamine-derived tetrahydroisoquinoline (TIQ) alkaloid by cocaine and by desmethylimipramine (DMI), Fed. Proc. (In press).Google Scholar
  17. Majchrowicz, E. and J.H. Mendelson, 1971. Blood methanol concentrations during experimentally induced ethanol intoxication in alcoholics, J. Pharmacol. Exp. Ther. 179: 293.Google Scholar
  18. Murphree, H.E., L.A. Greenberg and R.B. Carroll, 1967. Neuro-pharmacological effects of substances other than ethanol in alcoholic beverages, Fed. Proc. 26: 1468.Google Scholar
  19. Mytilineou, C., G. Cohen and R. Barrett, 1973, Uptake, storage and release in vivo of a dopamine-derived tetrahydroisoquinoline (TIQ) alkaloid by sympathetic nerves of the iris, Fed. Proc. (In press).Google Scholar
  20. Robinson, T., 1968, The Biochemistry of Alkaloids, Springer-Verlag, New York.Google Scholar
  21. Schöpf, C. and H. Bayerle, 1934. Zur Frage der Biogenese der Isochinolinalkaloide: Die synthese des 1-methyl-6,7-dioxy-l,2, 3,4-tetrahydro-isochinolins unter physiologischen bedingungen, Liebig Ann. Chem. 513: 190.CrossRefGoogle Scholar
  22. Tennyson, V.M., G. Cohen, C. Mytilineou and R. Heikkila, 1973, 6,7-Dihydroxytetrahydroisoquinoline: Electron microscopic evidence for uptake into the amine-binding vesicles in sympathetic nerves of the rat iris and pineal gland. Brain Research (In press).Google Scholar
  23. Whaley, W.M. and T.R. Govindachari, 1951, Chapt. 2, The preparation of 3,4-dihydroisoquinolines and related compounds by the Bischler-Napieralski reaction and Chapt. 3, The Pictet-Spengler synthesis of tetrahydroisoquinolines and related compounds, Org. React. 6, 74 and 151.Google Scholar
  24. Zenker, N., 1966. The interaction of pyridoxal phosphate with tyrosine analogs, J. Med. Chem. 9: 826.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Gerald Cohen
    • 1
  1. 1.College of Physicians & SurgeonsColumbia UniversityNew YorkUSA

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