Observations on the Prevalence of the Signs and Symptoms Associated with Withdrawal During Continuous Observation of Experimental Intoxication and Withdrawal in Humans

  • Milton M. Gross
  • Eastlyn Lewis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 35)


The clinical study by Victor and Adams (1953) and the experimental studies of intoxication and withdrawal in humans by Isbell and his coworkers (1955), by Mendelson (1964) and by Mello (1972) have clearly established the importance of withdrawal in producing the signs and symptoms of the clinical picture associated with delirium tremens and related states (which are now recognized as manifestations of the withdrawal syndrome). The experimental studies also demonstrated that, even during the drinking period, many of these signs and symptoms appeared. The nature of the partial withdrawal and its relation to total withdrawal require clarification.


Sleep Disturbance Alcohol Intake Withdrawal Symptom Heavy Drinking Muscle Pain 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Milton M. Gross
    • 1
  • Eastlyn Lewis
    • 1
  1. 1.Div. of Alcoholism & Drug Dependence, Dept. of PsychiatryDownstate Medical CenterBrooklynUSA

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