Correlation of Urinary Biogenic Amines with Sleep Stages in Chronic Alcoholization and Withdrawal

  • Benjamin Kissin
  • Milton M. Gross
  • Irving Schutz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 35)


The chronic administration of alcohol causes dramatic changes in the urinary excretion of biogenic amines and their metabolites at the same time that it causes equally dramatic changes in the sleep pattern. Since the stages of sleep are said to be related to biogenic amine metabolism in the brain, it seemed reasonable to investigate the possible relationship between these two widely separated sets of phenomena.


Biogenic Amine Chronic Alcoholization Alcohol Withdrawal Mandelic Acid Tyrosine Hydroxylase Activity 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Benjamin Kissin
    • 1
  • Milton M. Gross
    • 1
  • Irving Schutz
    • 1
  1. 1.Div. of Alcoholism & Drug Dependence, Dept. of PsychiatryDownstate Medical CenterBrooklynUSA

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