Abstract
The majority of the reports concerning tolerance to the effects of cannabis, describe a rather rapidly developing tolerance. Already Loewe (1950) mentioned a weakening of the Cannabis ataxia after a few administrations. Later on, tolerance was found by Carlini (1968) and Silva c.s.(1968), using cannabis extract, and by McMillan (1970 a,b), Moreton (1970) and Ten Ham (1972), using tetrahydrocannabinol (Δ9-THC).
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ten Ham, M., den Tonkelaar, E.M., Koomen, J.M. (1973). Influence of Two Tetrahydrocannabinols (THC’s) on the Activity of Biotransformation Enzymes. In: Gross, M.M. (eds) Alcohol Intoxication and Withdrawal I. Advances in Experimental Medicine and Biology, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3234-3_11
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DOI: https://doi.org/10.1007/978-1-4684-3234-3_11
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