In Vitro Platelet Adhesiveness Methods of Study and Clinical Significance

  • Dominique Meyer
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 28)

Abstract

Wright demonstrated in 1941 that platelets adhere to glass (102). Her approach was revived by Hellem’s work in 1960 (40), which led to the discovery of the effect of ADP on platelets. Since then, there has been considerable interest in developing simplified laboratory procedures to measure platelet adhesiveness. It is usually assessed by methods utilizing the tendency of platelets to adhere to glass. Platelet counts are performed before and after blood has been exposed to a glass surface for variable periods of time. Platelet adhesiveness is expressed as the number of adhered platelets or,more commonly, as the percentage of platelets which adhere or stick to the beads.

Keywords

Citrate Aspirin Heparin Adenosine Oxalate 

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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Dominique Meyer
    • 1
  1. 1.Coagulation Department Institut de Pathologie CellulaireHôpital BicêtreFrance

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