Significance and Comparison of Two Methods for Platelet Aggregation

  • S. Coccheri
  • M. Alessandrini
  • L. Fregni
  • F. Fiorentini
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 28)


We have carried out a, comparative evaluation of two methods for the study of platelet aggregation: the photometric test of Born (2) and O’Brien (17), and the “Platelet Aggregation Test” (P.A.T. of Breddin (3).


Platelet Aggregation Collagen Aggregation Loose Aggregate Photometric Parameter Maximal Fall 
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  1. 1.
    Bang N. U., Heidenreich R. O., Matsuda M., Plasma protein requirements for human platelet aggregation. In “Platelet adhesion and aggregation in thrombosis: Countermeasures”. Trans. 18th AHN. Symp. Blood Detroit 1970. F. K. Schattauer Verl. Stuttgart. New York.Google Scholar
  2. 2.
    Born G. V. R., Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature, 194, 927, 1962.PubMedCrossRefGoogle Scholar
  3. 3.
    Breddin K., Ober die gesteigerte Thrombozytenagglutination bei Gefass-krankheiten. Schw. Med. Wschr. 95, 655, 1965.Google Scholar
  4. 4.
    Breddin K., Hach W., Agglutination und Adhesivität der Thrombozyten nach körperlicher Belastung. Thrombw Diath. haemorrh. 15, 109, 1968.Google Scholar
  5. 5.
    Breddin K., Kryzwanek H. J., Plasma factors for platelet aggregation. Acta Med. Scand. suppl. 525, 15, 1971.Google Scholar
  6. 6.
    Coccheri S., D’Antuono G., Alessandri M., Garcia Condebru J., The initiation of clotting in lipaemic blood; contact phase and platelet participation. Hemostase 6, 339, 1966.PubMedGoogle Scholar
  7. 7.
    Coccheri S., Alessandri M., De Rosa V., Platelets and contact activation of blood clotting. Influence of some aggregation inhibitors. Acta Med. Scand. suppl. 525, 253, 1971.Google Scholar
  8. 8.
    Cronberg S., Kubisz P., Caen J. P., Demonstration of a plasmatic cofactor different from fibrinogen necessary for platelet release by ADP and adrenaline. Thromb. Diath. haemorrh. 24, 409, 1970.PubMedGoogle Scholar
  9. 9.
    Danta G., Second phase platelet aggregation induced by ADP in patients with cerebral vascular disease and in control subjects. Thromb. Diath. haemorrh. 23, 159, 1970.PubMedGoogle Scholar
  10. 10.
    Favero A., Personal communication.Google Scholar
  11. 11.
    Goldenfarb P. B., Cathey M. H., Cooper G. R., The determination of ADP induced aggregation in normal men. Atherosclerosis 12n 335, 1970.CrossRefGoogle Scholar
  12. 12.
    Holmsen H., Rozenberg M. C., Platelet disaggregation and refractoriness to ADP. Acta Med. Scand. suppl. 525, 113, 1971.PubMedGoogle Scholar
  13. 13.
    Kerr J. W., Mcaulay I., Pirrie R., Bronte Stewart B., Platelet aggregation by phospholipids and free fatty acids. Lancet 1, 1296, 1965.PubMedCrossRefGoogle Scholar
  14. 14.
    Mannucci P. M., Round-the-table conference on normal and modified platelet aggregation. Discussion. Acta Med. Scand. suppl. 525, 55, 1971.Google Scholar
  15. 15.
    Massini P., Löscher E. F., The induction of the release in human blood platelets by close cell contact. Thromb. Diath. haemorrh. 25, 13, 1971.PubMedGoogle Scholar
  16. 16.
    Mcdonald L., Edgill M., Coagulability of blood in ischaemic heart disease. Lancet, 2, 457, 1957.CrossRefGoogle Scholar
  17. 17.
    O’Brien J. R., Platelet aggregation. II. Some results from a new method of study. J. Clin. Path. 15, 446, 1962.PubMedCrossRefGoogle Scholar
  18. 18.
    O’Brien J. R., Heywood J. B., Heady J. A., The quantity of platelet aggregation induced by four compounds: a study in relation to myocardial infarction. Thromb. Diath. haemorrh. 26, 752, 1966.Google Scholar
  19. 19.
    O’Brien J. R., Heywood J. B., A comparison of platelet stickiness tests during an Atromid trial. Thromb. Diath. haemorrh. 26, 768, 1966.Google Scholar
  20. 20.
    O’Brien J. R., Platelet stickiness tests. Coagulation 1, 311, 1968.Google Scholar
  21. 21.
    O’Brien J. R., Woodhouse M. A., Platelet: their size, shape, and stickiness in vitro: degranulation and propinquity. Exp. Biol. Med. 3, 90, 1968.Google Scholar
  22. 22.
    O’Brien J. R., Etherington M., Jamieson S., Refractory state of platelet aggregation with major operations. Lancet, 2, 741, 1971.PubMedCrossRefGoogle Scholar
  23. 23.
    O’Brien J. R., This volume.Google Scholar
  24. 24.
    Sano T., Boxer M. G. J., Boxer L. A., Yokohama M., Platelet sensitivity to aggregation in normal and diseased groups. Thromb. Diath. haemorrh. 25, 524, 1971.PubMedGoogle Scholar
  25. 25.
    Vermylen J., Donati M. B., De Gaetano G., Protein requirement for platelet aggregation. Acta Med. Scand. suppl. 525, 19, 1971.Google Scholar
  26. 26.
    Wright H. P., Changes in the adhesiveness of blood platelets following parturition and surgical operations. J. Clin. Path. 54, 461, 1942.Google Scholar
  27. 27.
    Zbinden G., Na Laurate induped thrombocytopenia. A convenient model for the investigation of acute thrombosis. II Congress. Int. Soc. Thrombosis and Haemostasis. Oslo, July 1971, Abstract Book p. 276.Google Scholar
  28. 28.
    Zbinden G., Grimm L., Muheim M., Aggregation of platelets remaining in circulation after acute thrombosis. Thromb. Diath. haemorrh. 25, 517, 1971.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • S. Coccheri
    • 1
  • M. Alessandrini
    • 1
  • L. Fregni
    • 1
  • F. Fiorentini
    • 1
  1. 1.Institute for Occupational Medicine - Division for Social Medicine and Coagulation UnitUniversity of BolognaItaly

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