Platelet Factor-4. Methods of Study

  • M. B. Donati
  • M. Palester-Chlebowczyk
  • G. de Gaetano
  • J. Vermylen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 28)


“Platelet Factor-4” (PF-4) indicates one or more factors exhibiting several biological functions (for review, see ref.3), the best known of which is the ability of neutralizing the anti- clotting activity of heparin; PF-4 is also able to neutralise the anticlotting activity of some fibrinogen degradation products and to induce non-enzymatic polymerization of fibrinogen and its derivatives, a phenomenon known as “paracoagulation”.


Adenosine Diphosphate Platelet Factor Thrombin Time Fibrinogen Degradation Product Heparin Concentration 
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  1. 1.
    De Gaetano G., Vermylect J., Verstraete M., Platelet aggregation by a specific human immunoglobulin preparation. Thrombos. Diathes. haemorrh., 24, 419, 1970.Google Scholar
  2. 2.
    De Gaetano G., Vermylect J., Verstraete M., Platelet aggregation by Thrombofax. Acta Univ. Carolinae Med., 1972, in press.Google Scholar
  3. 3.
    Doeati M. B., Peles Ter-Chlebowczyk M., De Gaetmo G., Vermylm J., Platelet factor-4, I. Properties and clinical significance. This volume.Google Scholar
  4. 4.
    Godal H. C., The anti-heparin effect of platelets. Scand. J. Clin. Lab. Invest., 14, 223, 1962.CrossRefGoogle Scholar
  5. 5.
    Harada K., Zucker M. B., Simultaneous development of platelet factor 4 activity and release of 14C-serotonin. Thrombos. Diathes. haemorrh., 25, 41, 1971.Google Scholar
  6. 6.
    Kubisz P., Sultan Y., Delobel J., Caen J., Mesure de la libération du facteur plaquettaire 4 (EP 4) dans les thrombopathies constitutionelles et acquises. Rev. Europ. Etudes Clin. Biol., 15, 698, 1970.Google Scholar
  7. 7.
    Louis J., Salmon J., Etude du syndrome de coagulation intravas cul aire secondaire aux réactions anaphylactiques du lapin. Rôle du facteur 4 plaquettaire. Comptes rendus des séances de la Société de Biologie, 163, 2778, 1969.Google Scholar
  8. 8.
    Mamucci P. M., Discussion, in Acta Med. Scazid., suppl. 525, 551 1971.Google Scholar
  9. 9.
    Niewiarowski S., Poplawski A., Lipinski B., Farbiszewski R., The release of platelet clotting factors during aggregation and viscous metamorphosis. Exp. Biol. Med., 3, 121, 1968.Google Scholar
  10. 10.
    Itiewiarowski S., Thomas D. P., Platelet factor 4 and adenosine diphosphate release during human platelet aggregation. Nature, 222, 1269, 1969.CrossRefGoogle Scholar
  11. 11.
    Verstraete M., Platelet factors. Thrombos. Diathes. haemorrh., suppl. 20, 397, 1966.Google Scholar
  12. 12.
    Youssep A. Barkhan P., Release of platelet factor 4 by adenosine diphosphate and other platelet-aggregating agents. Brit. Med. J., 1, 746, 1968.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • M. B. Donati
    • 1
  • M. Palester-Chlebowczyk
    • 1
  • G. de Gaetano
    • 1
  • J. Vermylen
    • 1
  1. 1.Laboratory of Blood CoagulationUniversity of LeuvenBelgium

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