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Platelet Factor-4 Properties and Clinical Significance

  • M. B. Donati
  • M. Palester-Chlebowczyk
  • G. de Gaetano
  • J. Vermylen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 28)

Abstract

In 1948, Conley and coworkers (2) observed that patients with thrombocytopenia had an increased sensitivity to heparin and suggested that platelets could counteract the anticoagulant effect of heparin. This observation was subsequently confirmed by other workers, who demonstrated that platelets contain a heparin-neutralizing substance (21, 42) referred to as Platelet Factor-4 (PF-4) (10); in 1957, Deutsch and coworkers (11) provided evidence that PF-4 is a real platelet and not a plasma factor adsorbed on the platelet surface. This factor was also shown to be different from the platelet thromboplastic factor (platelet factor-3) (43). Little is known, however, about the mechanism by which heparin is neutralized by platelets. The existence of weak “heparin-platelet” complexes has been suggested (31, 38), but direct evidence for such complexes still is lacking. Antiheparin activity of platelets was shown to be easily extracted from platelet homogenates with saline or buffer and to be insoluble in lipid solvents (11, 43).

Keywords

Platelet Aggregation Idiopathic Thrombocytopenic Purpura Platelet Factor Release Reaction Aspirin Ingestion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • M. B. Donati
    • 1
  • M. Palester-Chlebowczyk
    • 1
  • G. de Gaetano
    • 1
  • J. Vermylen
    • 1
  1. 1.Laboratory of Blood CoagulationUniversity of LeuvenBelgium

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