Metabolic and Endocrine Functions of Rats Conditioned to Noble-Collip Drum Trauma

  • Š. Németh
  • M. Vigaš
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 33)


A great deal of research work has already been done on the changes in endocrine and metabolic function in rats adapted to Noble-Collip drum trauma (9,16,19,24,25). However, final conclusions about these problems cannot yet be made. This is understandable as there is lack of knowledge about the basic nature of this type of trauma, Mechanical energy applied to the body of the animals was considered to be the main factor causing injury (9). However, some of our recent work (30,31) made it clear that a more active part is taken by the injured animals themselveso They are trying to escape from the unexpected and apparently dangerous situation by doing active muscular work. Both central nervous influences and afferent signals from the periphery may lead to increased catecholamine (33) and corticosterone secretion (17). Vasoconstriction of the portal bed (13) with subsequent mesenteric pooling (27) loss of plasma and hemoconcentration (1) may be the consequences of the former0 Muscular work is done under rather unfavourable conditions. There exists hypoxia which, though facilitating glucose entry and phosphorylation in muscle (18), leads to an excessive accumulation of lactate, considered by some authors to be an important factor contributing to the irreversibility of shock (28).


Carbon Tetrachloride Corticosterone Level Endocrine Function Plasma Corticosterone Amino Nitrogen 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Š. Németh
    • 1
  • M. Vigaš
    • 1
  1. 1.Institute of Experimental EndocrinologySlovak Academy of SciencesBratislavaCzechoslovakia

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