Further Experiments on the Role of Phosphate in the Local Regulation of Blood Flow
Adenosine and its compounds, in particular ADP and ATP, have long been known to exert strong vasodepressor effects. These compounds have often been suggested to play a role in fundamental circulatory responses: their possible association with exercise hyperaemia in skeletal muscle has been mooted ever since the first tentative suggestions of this kind were made by Zipf (1931) and Rigler (1932); and their possible contribution to traumatic shock since the work of Bennet & Drury (1931) and Zipf (1931). Zipf (1931) also posed the question of their release following simple circulatory arrest. The local dilator effect of ATP on resistance vessels was clearly demonstrated by Stoner & Green (1945) who described erythema and a rise in temperature of forearm skin following close arterial injections of this compound. This vasodilator effect has since been described and measured many times in experiments on animals as well as man.
KeywordsCalcium Phosphate Soleus Muscle Interstitial Fluid Dihydrogen Phosphate Resistance Vessel
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