Hypothalamic Catecholamines and Adrenergic Innervation of Hypothalamic Blood Vessels. Potential Role in Shock

  • E. T. Angelakos
  • M. P. King
  • L. Carballo
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 33)


Previous studies by a number of investigators have established that the hypothalamus contains the highest concentration of norepinephrine (NE) among all regions of the brain (3,4,12,13,14, 24,26). This appears to be true of all species that have been studied. Results from our own studies in a number of laboratory species are shown in Table 1. We have also made extensive studies on the distribution of NE in various regions of the brain in the cat and squirrel monkey. These results are summarized in Table 2 and indicate that there are no striking differences in this respect between the feline and primate. The results obtained in the cat agree with previous findings (3, 18). Of all the tissues examined (Table 2) the hypothalamus had the highest concentration of norepinephrine (NE).


Squirrel Monkey Superior Cervical Ganglion Adrenergic Nerve Adrenergic Neuron Adrenergic Innervation 


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  1. 1.
    Ariden, N.E., Dahlstrom, A., Fuxe, K., Olson, L. & Ungerstedt, U. (1966) Experientia 22:44.CrossRefGoogle Scholar
  2. 2.
    Angelakos, E. T., Irvin, J.D. & King, M.P. (1970) Fed. Proc. 29:416A.Google Scholar
  3. 3.
    Bertler, A. & Rosengren, E. (1959) Acta physiol. Scand. 47:350.Google Scholar
  4. 4.
    Carlsson, A. (1959) Pharm. Rev., 11:490.Google Scholar
  5. 5.
    Carlsson, A., Falck, B. & Hillarp, N-A. (1962) Acta physiol. Scando 56: suppl. 196.Google Scholar
  6. 6.
    Dahlstrom, A. & Fuxe, K. (1965) Acta physiol. Scand. 64: Suppl. 247.Google Scholar
  7. 7.
    D’Alecy, L.G. & Feiglo E.O. (1970) Fed. Proc. 29:520A.Google Scholar
  8. 8.
    Dollison, J. R., Bloor, B.M., Figueroa, A.F. & Loar, B.A. (1969) Surg. Forum 20:416.Google Scholar
  9. 9.
    Falck, B., Hillarp, N-Å., Thieme, G. & Torp, A. (1962) J. Histochemo Cytochem. 10:348.CrossRefGoogle Scholar
  10. 10.
    Falck, B., Mchedlishvili, G.I. & Owman, Ch. (1965) Acta Pharmacol. Toxicol. 23:133.CrossRefGoogle Scholar
  11. 11.
    Falck, B., Nielsen, K.C. & Owman, C. (1968) Scando J. Clin. Labo Invest. Suppl. 102: Sect VI, B.Google Scholar
  12. 12.
    Faxe, K. & Hokfelt, T. (1970) Central monoaminergic systems and hypothalamic function. In: The Hypothalamus, ed.: L. Martini, M. Motta and F. Fraschini. New York, Academic, 123.Google Scholar
  13. 13.
    Fuxe, K., Hokfelt, T. & Uhgerstedt, U. (1970) Morphological and functional aspects of central monoamine neurons. In: International Review of Neurobiology, ed.: C.C. Pfeiffer and J.R. Smythies. New York, Academic, 93.Google Scholar
  14. 14.
    Glowinski, J., Axelrod, J. & Iversen, L.L. (1966) J. Pharmacol. exptl. Therap. 153:30.Google Scholar
  15. 15.
    Hillarp, N-Å, Fuxe, K. & Dahlstrom, A. (1966). Pharmacol. Rev. 18:727.Google Scholar
  16. 16.
    Mitchell, G.A.G., (1956) Cardiovascular innervation. London: E. and S. Livingstone Ltd.Google Scholar
  17. 17.
    Nelson, E. & Renneis, M. (1970) Innervation of intracranial arteries. Brain 93:475.CrossRefGoogle Scholar
  18. 18.
    Reis, D.J. & Wurtman, R.J. (1968) Diurnal changes in brain norepinephrine. Life Sciences 7:91.CrossRefGoogle Scholar
  19. 19.
    Rosendorff, C. & Cranston, W.I. (1971) Circulation Res. 28:492.CrossRefGoogle Scholar
  20. 20.
    Ross, G. The regional circulation (1971) Ann. Rev. Physiol. 33:445.CrossRefGoogle Scholar
  21. 21.
    Schmidt, CF. (1934) The intrinsic regulation of the circulation in the hypothalamus of the cat. Am. J. Physiol. 110:137.Google Scholar
  22. 22.
    Schmidt, C.F. (1950) The cerebral circulation in health and disease. Springfield, Illinois: Charles C. Thomas.Google Scholar
  23. 23.
    Sokoloff, L. (1959) Pharmacol. Rev. 11:1.Google Scholar
  24. 24.
    Vogt J M. (1954) J. Physiol. 123:451.Google Scholar
  25. 25.
    Vogt, M. (1957) Brit. Med. Bull. 13:166.Google Scholar
  26. 26.
    Vogt, M. (1959) Pharmacol. Rev. 11:483.Google Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • E. T. Angelakos
    • 1
  • M. P. King
    • 1
  • L. Carballo
    • 1
  1. 1.Department of Physiology & BiophysicsHahnemann Medical College & HospitalPhiladelphiaUSA

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