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Hypothalamic Catecholamines and Adrenergic Innervation of Hypothalamic Blood Vessels. Potential Role in Shock

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Neurohumoral and Metabolic Aspects of Injury

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 33))

Abstract

Previous studies by a number of investigators have established that the hypothalamus contains the highest concentration of norepinephrine (NE) among all regions of the brain (3,4,12,13,14, 24,26). This appears to be true of all species that have been studied. Results from our own studies in a number of laboratory species are shown in Table 1. We have also made extensive studies on the distribution of NE in various regions of the brain in the cat and squirrel monkey. These results are summarized in Table 2 and indicate that there are no striking differences in this respect between the feline and primate. The results obtained in the cat agree with previous findings (3, 18). Of all the tissues examined (Table 2) the hypothalamus had the highest concentration of norepinephrine (NE).

These studies were supported by a Themis Research Project Grant from the Department of the Navy and by USPHS NIH Grants HE 13008 and NB 08664.

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References

  1. Ariden, N.E., Dahlstrom, A., Fuxe, K., Olson, L. & Ungerstedt, U. (1966) Experientia 22:44.

    Article  Google Scholar 

  2. Angelakos, E. T., Irvin, J.D. & King, M.P. (1970) Fed. Proc. 29:416A.

    Google Scholar 

  3. Bertler, A. & Rosengren, E. (1959) Acta physiol. Scand. 47:350.

    Google Scholar 

  4. Carlsson, A. (1959) Pharm. Rev., 11:490.

    Google Scholar 

  5. Carlsson, A., Falck, B. & Hillarp, N-A. (1962) Acta physiol. Scando 56: suppl. 196.

    Google Scholar 

  6. Dahlstrom, A. & Fuxe, K. (1965) Acta physiol. Scand. 64: Suppl. 247.

    Google Scholar 

  7. D’Alecy, L.G. & Feiglo E.O. (1970) Fed. Proc. 29:520A.

    Google Scholar 

  8. Dollison, J. R., Bloor, B.M., Figueroa, A.F. & Loar, B.A. (1969) Surg. Forum 20:416.

    Google Scholar 

  9. Falck, B., Hillarp, N-Å., Thieme, G. & Torp, A. (1962) J. Histochemo Cytochem. 10:348.

    Article  Google Scholar 

  10. Falck, B., Mchedlishvili, G.I. & Owman, Ch. (1965) Acta Pharmacol. Toxicol. 23:133.

    Article  Google Scholar 

  11. Falck, B., Nielsen, K.C. & Owman, C. (1968) Scando J. Clin. Labo Invest. Suppl. 102: Sect VI, B.

    Google Scholar 

  12. Faxe, K. & Hokfelt, T. (1970) Central monoaminergic systems and hypothalamic function. In: The Hypothalamus, ed.: L. Martini, M. Motta and F. Fraschini. New York, Academic, 123.

    Google Scholar 

  13. Fuxe, K., Hokfelt, T. & Uhgerstedt, U. (1970) Morphological and functional aspects of central monoamine neurons. In: International Review of Neurobiology, ed.: C.C. Pfeiffer and J.R. Smythies. New York, Academic, 93.

    Google Scholar 

  14. Glowinski, J., Axelrod, J. & Iversen, L.L. (1966) J. Pharmacol. exptl. Therap. 153:30.

    Google Scholar 

  15. Hillarp, N-Å, Fuxe, K. & Dahlstrom, A. (1966). Pharmacol. Rev. 18:727.

    Google Scholar 

  16. Mitchell, G.A.G., (1956) Cardiovascular innervation. London: E. and S. Livingstone Ltd.

    Google Scholar 

  17. Nelson, E. & Renneis, M. (1970) Innervation of intracranial arteries. Brain 93:475.

    Article  Google Scholar 

  18. Reis, D.J. & Wurtman, R.J. (1968) Diurnal changes in brain norepinephrine. Life Sciences 7:91.

    Article  Google Scholar 

  19. Rosendorff, C. & Cranston, W.I. (1971) Circulation Res. 28:492.

    Article  Google Scholar 

  20. Ross, G. The regional circulation (1971) Ann. Rev. Physiol. 33:445.

    Article  Google Scholar 

  21. Schmidt, CF. (1934) The intrinsic regulation of the circulation in the hypothalamus of the cat. Am. J. Physiol. 110:137.

    Google Scholar 

  22. Schmidt, C.F. (1950) The cerebral circulation in health and disease. Springfield, Illinois: Charles C. Thomas.

    Google Scholar 

  23. Sokoloff, L. (1959) Pharmacol. Rev. 11:1.

    Google Scholar 

  24. Vogt J M. (1954) J. Physiol. 123:451.

    Google Scholar 

  25. Vogt, M. (1957) Brit. Med. Bull. 13:166.

    Google Scholar 

  26. Vogt, M. (1959) Pharmacol. Rev. 11:483.

    Google Scholar 

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Authors and Affiliations

  1. Department of Physiology & Biophysics, Hahnemann Medical College & Hospital, Philadelphia, Pennsylvania, USA

    E. T. Angelakos, M. P. King & L. Carballo

Authors
  1. E. T. Angelakos
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  2. M. P. King
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  3. L. Carballo
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Editor information

Editors and Affiliations

  1. Experimental Research Department, Semmelweis Medical University, Budapest, Hungary

    Arisztid G. B. Kovách

  2. MRC Toxicology Unit, Medical Research Council Laboratories, Carshalton, Surrey, UK

    H. B. Stoner

  3. Department of Physiology and Biophysics, Hahnemann Medical College and Hospital, Philadelphia, Pennsylvania, USA

    John J. Spitzer

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© 1973 Plenum Press, New York

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Angelakos, E.T., King, M.P., Carballo, L. (1973). Hypothalamic Catecholamines and Adrenergic Innervation of Hypothalamic Blood Vessels. Potential Role in Shock. In: Kovách, A.G.B., Stoner, H.B., Spitzer, J.J. (eds) Neurohumoral and Metabolic Aspects of Injury. Advances in Experimental Medicine and Biology, vol 33. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3228-2_54

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  • DOI: https://doi.org/10.1007/978-1-4684-3228-2_54

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3230-5

  • Online ISBN: 978-1-4684-3228-2

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