Decreased 2,3-Diphosphoglycerate and Reduced Oxygen Delivery Following Massive Transfusion and Septicemic Shock

  • Harvey J. Sugerman
  • Leonard D. Miller
  • Maria Delivoria-Papadopoulos
  • Frank A. Oski
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 33)


Oxygen delivery has been demonstrated to be inadequate in patients in septicemic shock as manifested by an elevated mixed venous O2 saturation (1). The subsequent narrow arterio-venous (A-V) O2 content difference has been attributed to pre-capillary A-V shunting (2). Other possible causes could be decreased mitochondrial utilization of O2 (3) and decreased release of O2 from hemoglobin (4).


Septic Shock Cardiac Index Oxygen Delivery Massive Transfusion Content Difference 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Harvey J. Sugerman
    • 1
  • Leonard D. Miller
    • 1
  • Maria Delivoria-Papadopoulos
    • 1
  • Frank A. Oski
    • 1
  1. 1.Departments of Pediatrics and SurgeryUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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