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Decreased 2,3-Diphosphoglycerate and Reduced Oxygen Delivery Following Massive Transfusion and Septicemic Shock

  • Harvey J. Sugerman
  • Leonard D. Miller
  • Maria Delivoria-Papadopoulos
  • Frank A. Oski
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 33)

Abstract

Oxygen delivery has been demonstrated to be inadequate in patients in septicemic shock as manifested by an elevated mixed venous O2 saturation (1). The subsequent narrow arterio-venous (A-V) O2 content difference has been attributed to pre-capillary A-V shunting (2). Other possible causes could be decreased mitochondrial utilization of O2 (3) and decreased release of O2 from hemoglobin (4).

Keywords

Septic Shock Cardiac Index Oxygen Delivery Massive Transfusion Content Difference 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Maclean, L.D., Mulligan, W.G., McLean, A.P.H. & Duff, J.H. (1967) Ann Surg. 166:543.CrossRefGoogle Scholar
  2. 2.
    Siegel, J.H., Greenspan, M. & Del Guerico, L.R.M. (1967) Ann. Surg. 165:504.CrossRefGoogle Scholar
  3. 3.
    Mela, L., Bacalzo, L.V. & Miller, L.D. (1971) Am J Physiol 220:571.Google Scholar
  4. 4.
    Sugerman, H.J., Miller, L.D., Oski, F.A., Diaco, J., Delivoria-Papadopoulos, M. & Davidson, D. (1970) Clin Res. 18:418.Google Scholar
  5. 5.
    Benesch, R. & Benesch, R.E. (1967) Biochem Biophys Res 26:162.CrossRefGoogle Scholar
  6. 6.
    Chanutin, A. & Curnish, R.R. (1967) Arch Biochem. 96:121.Google Scholar
  7. 7.
    Oski, F.A., Miller, W., Delivoria-Papadopoulos, M. & Gottlieb, A.J. (1970) J Clin Invest 49:400.CrossRefGoogle Scholar
  8. 8.
    Oski, F.A., Gottlieb, A.J., Delivoria-Papadopoulos, M. & Miller, W.W. (1969) N Eng J Med 200:1165CrossRefGoogle Scholar
  9. 9.
    Edwards, M.J., Novy, M.J., Walters, C.L. & Metcalfe, J. (1968) J. Clin Invest 47:1851.CrossRefGoogle Scholar
  10. 10.
    Torrance, J., Jacobs, P., Restrepo, A., Eschback, J., Lenfant, C. & Finch, C.A. (1970) N Eng J Med 283:165.CrossRefGoogle Scholar
  11. 11.
    Miller, L.D., Sugerman, H.J., Miller, W.W., Delivoria-Papadopoulos, M., Diaco, J.F., Gottlieb, A.J. & Oski, F.A. (1970) Ann Surg 172:1051.Google Scholar
  12. 12.
    Malhausen, R., Astrup, P. & Kjeldsen, K. (1967) Scand J Clin Lab Invest 19:291.CrossRefGoogle Scholar
  13. 13.
    Lenfant, C., Torrance, J., English, E., Finch, C.A., Reynafarje, C., Ramos, J & Faura, J. (1968) J Clin Invest 47:2652.CrossRefGoogle Scholar
  14. 14.
    Miller, L.D., Oski, F.A., Diaco, J., Sugerman, H.J., Davidson, D. & Delivoria-Papadopoulos, M. (1970) Surgery 68:187.Google Scholar
  15. 15.
    Delivoria-Papadopoulos, M., Oski, F.A. & Gottlieb, A.J. (1969) Science 165:601.CrossRefGoogle Scholar
  16. 16.
    Oski, F.A., Marshall, B.E., Cohen, P.J., Sugerman, H.J. & Miller, L.D. (1971) Ann Int Med 74:44.CrossRefGoogle Scholar
  17. 17.
    Travis, S.F., Sugerman, H.J., Ruberg, R.J., Delivoria-Papadopoulos, M., Miller, L.D. & Oski, F.A. N Eng J Med (in press)Google Scholar
  18. 18.
    Lichtman, M.A., Miller, D.R., Cohen, J. & Waterhouse, C. (1971) Ann Int Med 74:562.CrossRefGoogle Scholar
  19. 19.
    Valtis, D.J. & Kennedy, A.C. (1954) Lancet 1:119.CrossRefGoogle Scholar
  20. 20.
    Bunn, H.F., May, M.H., Kocholaty, W.F., & Shields, C.E. (1969) J Clin Invest 48:311.CrossRefGoogle Scholar
  21. 21.
    Sugerman, H.J., Davidson, D.T., Vibul, S., Delivoria-Papadopoulos, M., Miller, L.D. & Oski, F.A. (1970) Surg Gynec Obstet 131:733.Google Scholar
  22. 22.
    Oski, F.A., Travis, S.F., Miller, L.D., Delivoria-Papadopoulos, M. & Cannon, E. (1971) Blood 37:52.Google Scholar
  23. 23.
    Pollock, T.W., Sugerman, H.J., Oski, F.A., Rosato, E.F. & Miller, L.D. (1971) Fed Proc 30:1965.Google Scholar
  24. 24.
    Oski, F.A. & Deliveria-Papadopoulos, M. (1970) J. Pediatr 77:941.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Harvey J. Sugerman
    • 1
  • Leonard D. Miller
    • 1
  • Maria Delivoria-Papadopoulos
    • 1
  • Frank A. Oski
    • 1
  1. 1.Departments of Pediatrics and SurgeryUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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