Environmental Temperature and the Metabolic Response to Injury — Plasma Proteins
Few studies of the now well-known changes in plasma proteins after injury take into account the environmental temperature of the subject; the work of Davies, Liljedahl & Birke (l969) on patients who had sustained burns is one exception. Changes in the plasma protein fractions after injury have been reviewed and summarised by Owen (l967):— a1-, and a2-globulin increass and there is a transient decrease in plasma albumin concentration. With the introduction of quantitative immunodiffusion techniques it was found that numerous proteins change in a variety of ways after trauma. The group known as ‘acute phase reactants’ which include fibrinogen, C-reactive protein,a1 acid glycoprotein, haptoglobin, and ceruloplasmin, all show an increased plasma concentration after injury (Werner & Cohnen, 1969). Each protein has a characteristic response which is not related to the nature of the trauma (Koj, 1970). In contrast, the plasma concentration of albumin, thyroxine-binding pre-albumin and transferrin decreases after injury (Gordon, 1970).
KeywordsEnvironmental Temperature Acute Phase Reactant Plasma Albumin Increase Plasma Concentration Acid Glycoprotein
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