Energy and Tissue Fuel in Human Injury and Sepsis
The loss of body weight has been a prominent feature of the response to injury or sepsis since the earliest clinical descriptions of these conditions. It was evident that the extent of weight loss tended to parallel the magnitude of the injury or sepsis. Subsequent observations revealed that the degree of weight loss is largest in males, younger adults, well-muscled individuals, and those with good previous nutrition. The weight loss is less in the female, the elderly, the poorly muscled, the nutritionally depleted. However, the underlying alterations in energy requirements and tissue fuel associated with injury and sepsis remain incompletely understood and are the subject of this discussion.
KeywordsCaloric Expenditure Specific Dynamic Action Urea Synthesis Oxygen Difference Urea Excretion
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