Peripheral and Cardiac Factors in Experimental Septic Shock

  • Lerner B. Hinshaw
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 33)


The insidious and sometimes precipitous development of septic shock in man involves mechanisms not clearly understood. Cardiovascular changes have been reported to occur within seconds following an intravenous injection of endotoxin in dogs £5,7,19,22), and at variable times after injection of endotoxin in monkeys (8,10,13) or live E. coli organisms in the canine and primate species (3,11,14,15). Although the animal shock model has been studied extensively in recent years, the precise mechanisms involved in the early development of shock are not clearly understood. Recent emphasis has been focused on the causes of inadequate tissue perfusion in this form of shock. Of particular importance have been studies in which cardiac output decreased significantly in the early phase of shock. Several explanations have been proposed to account for the early decrease in flow and these will be the subject of this presentation.


Cardiac Output Septic Shock Myocardial Blood Flow Coronary Perfusion Pressure Systemic Hypotension 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Lerner B. Hinshaw
    • 1
  1. 1.Veterans Administration Hospital, and Departments of Physiology and Biophysics and SurgeryUniversity of Oklahoma Medical CenterOklahoma CityUSA

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