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Influence of Endotoxin on Adipose Tissue Metabolism

  • J. A. Spitzer
  • A. G. B. Kovach
  • S. Rosell
  • P. Sandor
  • J. J. Spitzer
  • R. Storck
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 33)

Abstract

Adipose tissue representa a relatively large tissue mass, about 15% of body weight, receiving a substantial portion of the cardiac output. Regional vasomotor adjustments in this vascular bed, therefore, are very likely to influence the “overall” hemodynamics of the animal. In addition, the mobilization of free fatty acids (FFA) from the energy rich triglyceride stores of adipose tissue is also dependent on an adequate blood supply. Since in endotoxic shock vascular responses are drastically altered, it became of interest to study the effect of endotoxin administration on adipose tissue metabolism.

Keywords

Adipose Tissue Free Fatty Acid Free Fatty Acid Level Endotoxic Shock Endotoxin Administration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

MABP

mean arterial blood pressure

CO

cardiac output

HR

heart rate

BF

blood flow

NE

norepinephrine

FFA

free fatty acids

GLY

glycerol

L

lactate

GLU

glucose

SC

subcutaneous

O

omental

M

mesenteric

TG

triglyceride

cAMP

cyclic 3′,5′-adenosine monophosphate

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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • J. A. Spitzer
    • 1
  • A. G. B. Kovach
    • 1
    • 2
  • S. Rosell
    • 1
  • P. Sandor
    • 1
    • 3
  • J. J. Spitzer
    • 1
  • R. Storck
    • 1
  1. 1.Department of Physiology and BiophysicsMedical College and HospitalPhiladelphiaUSA
  2. 2.National Science FoundationUSA
  3. 3.Heart Association of South-eastern PennsylvaniaUSA

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