Dexamethasone (DXM) Effect on the Histamine-Releasing Activity of Endotoxin

  • William Schumer
  • R. P. Obernolte
  • P. R. Erve
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 33)


It has been proposed that bacterial endotoxins possess little or no intrinsic toxic activity, but exert their myriad pathophysiological effects by an antigenic action (l2). Weil and Spink reported a marked resemblance between the effects of anaphylactic and endotoxic shock (14). Lichtenstein and associates incubated endotoxin from Veillonella alcalescens or Serratia marcencens with guinea pig complement and were able to produce an anaphylatoxin which had a contractile effect on guinea pig ileum (8). This action was significantly inhibited by antihistamines, indicating a histamine release. In this connection, Hlnshaw and co-workers found that plasma histamine increased following induction of endotoxic shock (5). The role of histamine in anaphylactic shock has been well documented (7), however its role in endotoxic shock has received scant attention. The research efforts of our laboratory have been directed toward the elucidation of the mechanism and treatment of septic shock. Therefore, we decided to study the conditions required for Escherichia coli endotoxin-induced histamine release and then, the effect of the potent anti-endotoxic agent, DXM, on this releasing activity (4).


Histamine Release Peritoneal Exudate Endotoxic Shock Histamine Content Histamine Concentration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Bjørneboe, M., Fischel, E.M. & Stoerk, H.C. (1951) J. Exp. Med. 93, 39.Google Scholar
  2. 2.
    Blumer, H., Richter, M. Gua Lim, F. & Rose, B. (1962) J. Immunology 88, 669.Google Scholar
  3. 3.
    Fischel, E.E., Vaughan, J.H. & Photopoulos, C. (1952) Proc. Soc. Exp. Biol. Med. 81, 344.CrossRefGoogle Scholar
  4. 4.
    Fukuda, T. & Hata, N. (1969) Japan J. Physiol. 19, 509.CrossRefGoogle Scholar
  5. 5.
    Hinshaw, L.B., Vick, J.A., Carlson, C.H. & Fan, Y. (1960) Proc. Soc. Exp. Biol. Med. 104, 379.CrossRefGoogle Scholar
  6. 6.
    Jennings, J.F. (1966) J. Immunology 96, 409.Google Scholar
  7. 7.
    Lecomte, J. CIBA Foundation Symposium on Histamine, edited by G.E.W. Wolsteinholme and C.M. O’Connor. Boston: Little, Brown and Company, 1956 p.173.CrossRefGoogle Scholar
  8. 8.
    Lichtenstein, L.M., Gewurz, H., Adkinson, N.F.Jr., Shin, H.S. & Mergenhagen, S.E. (1969) Immunology 16, 327.Google Scholar
  9. 9.
    Malkiel, S. & Hargis, B.J. (1952) J. Immunology 69, 217.Google Scholar
  10. 10.
    Norn, S. (1966) Acta Pharmacol. Toxicol. 25, 281.CrossRefGoogle Scholar
  11. 11.
    Shore, P.A., Burkhalter, A. & Cohn, V.H.Jr. (1959) J.Pharmacol 127, 182.Google Scholar
  12. 12.
    Stetson, C.A., Jr. (1955) J. Exp. Med. 101, 421.CrossRefGoogle Scholar
  13. 13.
    Surjan, L., Jr. & Csaba, C. (1969) Z. Mikro. Anat. Forsch. 80, 321.Google Scholar
  14. 14.
    Weil, M.H. & Spink, W.W. (1957) J. Lab. Clin. Med. 50, 501.Google Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • William Schumer
    • 1
  • R. P. Obernolte
    • 1
  • P. R. Erve
    • 1
  1. 1.Department of SurgeryUniversity of Illinois College of Medicine at Veterans Administration West Side HospitalUSA

Personalised recommendations