Dexamethasone (DXM) Effect on the Histamine-Releasing Activity of Endotoxin
It has been proposed that bacterial endotoxins possess little or no intrinsic toxic activity, but exert their myriad pathophysiological effects by an antigenic action (l2). Weil and Spink reported a marked resemblance between the effects of anaphylactic and endotoxic shock (14). Lichtenstein and associates incubated endotoxin from Veillonella alcalescens or Serratia marcencens with guinea pig complement and were able to produce an anaphylatoxin which had a contractile effect on guinea pig ileum (8). This action was significantly inhibited by antihistamines, indicating a histamine release. In this connection, Hlnshaw and co-workers found that plasma histamine increased following induction of endotoxic shock (5). The role of histamine in anaphylactic shock has been well documented (7), however its role in endotoxic shock has received scant attention. The research efforts of our laboratory have been directed toward the elucidation of the mechanism and treatment of septic shock. Therefore, we decided to study the conditions required for Escherichia coli endotoxin-induced histamine release and then, the effect of the potent anti-endotoxic agent, DXM, on this releasing activity (4).
KeywordsHistamine Release Peritoneal Exudate Endotoxic Shock Histamine Content Histamine Concentration
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