Alterations of Mitochondrial Structure and Energy-Linked Functions in Hemorrhagic Shock and Endotoxemia

  • Leena M. Mela
  • Leonard D. Miller
  • Leonardo V. BacalzoJr.
  • Kenneth Olofsson
  • Raleigh R. WhiteIV
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 33)


Gross metabolic aspects of injury have been under intensive study for years and thus a lot of useful information about the metabolic effects of injury is available (l,2). On the other hand, until a couple of years ago, there were hardly any reports about specific cellular metabolic changes occurring during clinical or experimental shock reactions, such as the hypovolemic hemorrhagic shock or the normovolemic, primarily septic shock reaction, endotoxemia. Recently a few reports have appeared in the literature, indicating a block at the mitochondrial level of the cellular metabolic pathway (3–12).


Lysosomal Enzyme Respiratory Activity Liver Mitochondrion Tissue Hypoxia Acid Phosphatase Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Baue, A.E. (1968) Surg. Gyn. Obstet. 127:849.Google Scholar
  2. 2.
    Berry, L.J. In Microbial Toxins, Vol. V, Bacterial Endotoxins (Kadis, S., Weinbaum, G. and Ajl, S.J., Eds.) Academic Press, New York and London, 1971, p. 165.Google Scholar
  3. 3.
    Schumer, W., Das Gupta, T.R., Moss, G.S. & Nyhus, L.M. (1970) Ann. Surgery 171:875.CrossRefGoogle Scholar
  4. 4.
    Baue, A.E. & Sayeed, M.M. (1970) Surgery, 68:40.Google Scholar
  5. 5.
    DePalma, R.G., Harano, Y., Robinson, A.V. & Holden, W.D. (1970) Surg. Forum, 21:3.Google Scholar
  6. 6.
    Mela, L., Bacalzo, L.V., White, R.R. & Miller, L.D. (1970) Surg. Forum, 21:6.Google Scholar
  7. 7.
    Baue, A.E., Wurth, M.A. & Sayeed, M.M, (1970) Surg. Forum, 21:8.Google Scholar
  8. 8.
    Reed, R.C., Erve, P.R., Das Gupta, T.K. & Schumer, W. (1970) Surg.Forum, 21:13.Google Scholar
  9. 9.
    Mela, L., Bacalzo, L.V. & Miller, L.D. (1971) Am.J. Physiol. 220:571.Google Scholar
  10. 10.
    Sayeed, M.M. & Baue, A.E. (1971) Am.J. Physiol. 220:1275.Google Scholar
  11. 11.
    Schumer, W., Erve, P.R. & Obernolte, R.P. (1971) Surg. Gyn. Obstet. 133:433.Google Scholar
  12. 12.
    Lavine, L., Harano, Y. & de Palma, R.G. (1971) Surg. Forum 22:5.Google Scholar
  13. 13.
    Mela, L., Olofsson, K., Miller, L.D., Bacalzo, L.V. & White, R.R. (1971) Surg. Forum, 22:19.Google Scholar
  14. 14.
    Bacalzo, L.V., Cary, A.L., Miller, L.D. & Parkins, W.M. (1971) Surgery, 70:555.Google Scholar
  15. 15.
    Mela, L., Miller, L.D., Diaco, J.F. & Sugerman, H.J. (1970) Surgery, 68:541.Google Scholar
  16. 16.
    Fiske, G.H. & Subbarow, Y. (1925) J. Biol. Chem. 66:375.Google Scholar
  17. 17.
    Silver, I.A. In: Oxygen Measurements In Blood and Tissues and Their Significance (Payne, J.P. and Hill D.W., Eds) Little, Brown and Company, Boston, 1966, p.135.Google Scholar
  18. 18.
    Cater, D.B. & Silver, I.A. In: Reference Electrodes, Theory and Practice (Ives, D.J.G. and Janz, G.J., Eds.) Academic Press, New York and London, 1961, p.464.Google Scholar
  19. 19.
    Lubbers, D.W. In: Oxygen Transport in Blood and Tissue (D.W. Lubbers, V.C. Luft, G. Theirs and E. Witzlab, Eds), Georg Thieme Verlag, Stuttgart, 1968, p.124.Google Scholar

Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • Leena M. Mela
    • 1
    • 2
  • Leonard D. Miller
    • 1
    • 2
  • Leonardo V. BacalzoJr.
  • Kenneth Olofsson
    • 1
    • 2
  • Raleigh R. WhiteIV
  1. 1.Shock and Trauma UnitHospital of the University of PennsylvaniaPhiladelphiaUSA
  2. 2.Harrison Department of Surgical Research, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

Personalised recommendations