Some in Vitro and in Vivo Effects of a New Prostaglandin Derivative

  • B. David Polis
  • Anne Marie Grandizio
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 33)


On the simplistic premise that an anoxic-fatigue stress, like acceleration, could be defined in terms of energy demand under conditions of limited supply, we searched for molecular probes which would reveal or reflect those regulatory mechanisms pertinent to the bioenergetic pathways involved in adaptation to stress. It was our expectation that the exhaustion of adaptive events, and the onset of pathology would be presignaled by molecular changes which might afford a biochemical index or end point to stress tolerance. Such information would be useful also to amortize, pharmacologically, the energetic cost of a defensive reorganization against stress, and thereby enhance the survival of a crisis period.


Adenylate Kinase Crisis Period Total Phospholipid Phosphatidyl Ethanolamine Phosphatidyl Glycerol 
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Copyright information

© Plenum Press, New York 1973

Authors and Affiliations

  • B. David Polis
    • 1
  • Anne Marie Grandizio
    • 1
  1. 1.Edith Polis Biochemistry LaboratoryU.S. Naval Air Development CenterWarminsterUSA

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