Glucose Homeostasis in the Postoperative State
The postoperative period is a unique and complex state caused by the controlled injury of surgery, anesthetic agents, and starvation. These factors produce profound physiologic and metabolic alterations which subject homeostatic mechanisms to stress. The glueose-insulin feedback system operates in an altered milieu of increased catecholamines and corticosteroids, liver glycogen depletion and changes in perfusion patterns. We have examined the response to insulin in the early and later postoperative periods to determine insulin clearance, hepatic glucose output and peripheral utilization of glucose.
KeywordsHepatic Glucose Output Hepatic Arterial Blood Flow Total Hepatic Blood Flow Arterial Glucose Peripheral Utilization
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