Secretory and Systemic Cell-Mediated and Humoral Immune Response in Humans and Guinea Pigs to the Inactivated Influenza Virus Vaccine

  • R. H. Waldman
  • N. Gadol
  • P. F. Jurgensen
  • G. N. Olsen
  • J. E. JohnsonIII
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 31)


In the past few years, there has been a great deal of interest in what has been called the secretory immunologic system (1–6). A stimulus has been the basic immunologic finding that the predominant immunoglobulin in external secretions is secretory IgA, i.e., dimerized IgA containing secretory component (6–8). However, in 1927, Besredka (9) had already described his work and the work of others on the production of immunity against pathogens of the gastrointestinal tract by direct stimulation through the feeding of antigens. Sporadic investigations of the secretory immunologic system ensued, but it was not until the mid 1960’s that immunolo-gists became greatly interested.


Influenza Virus Macrophage Migration Nasal Secretion Splenic Lymphocyte Diphtheria Toxoid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • R. H. Waldman
    • 1
  • N. Gadol
    • 1
  • P. F. Jurgensen
    • 1
  • G. N. Olsen
    • 1
  • J. E. JohnsonIII
    • 1
  1. 1.University of Florida College of MedicineGainesvilleUSA

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