Abstract
The red blood cell has occupied a central position in studies of how man adapts to high altitudes. With the discovery that the level of DPG has important implications for erythrocyte oxygen affinity, the study of red cell metabolism at high altitudes has taken on new and greater significance. Change in the level of DPG is most certainly related to changes in the levels of other red cell glycolytic intermediates. The appropriate next steps in understanding the mechanism of the increase in DPG are to ascertain which of the enzymes of glycolysis are activated by altitude exposure, and to identify the stimuli which are operating on this enzyme or enzymes. We initiated this next step with studies in Leadville, Colorado, elevation 10,200 feet.
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References
Brewer, G.J., Oelshlegel, F.J., Jr., and Eaton, J.W. (1972) Biochemical, Physiological, and Genetic Factors in the Regulation of Mammalian Erythrocyte Metabolism and DPG Levels. In “IVth Alfred Benzon Symposium”, Munksgaard, Copenhagen, In press.
Brewer, G.J. and Powell, R.D. (1966). The Adenosine Triphosphate Content of Glucose-6-Phosphate Dehydrogenase Deficient and Normal Erythrocytes Including Studies of a Glucose-6-Phosphate Dehydrogenase Deficient Man With “Elevated Erythrocytic ATP”. J. Lab. Clin. Med. 67: 726.
Duhm, J. and Gerlach, E. (1971). On the Mechanisms of the Hypoxia Induced Increase of 2,3-Diphosphoglycerate in Erythrocytes. Pflugers Arch. 326: 254.
Eaton, J.W., Brewer, G.J., and Grover, R. (1969). Role of Red Cell 2,3-Diphosphoglycerate in the Adaptation of Man to Altitude. J. Lab. Clin. Med. 73: 603.
Keitt, A.S. (1971). Reduced Nicotinamide Adenine Dinucleotide- Linked Analysis of 2,3-Diphosphoglyceric Acid: Spectrophotometric and Flurometric Procedures. J. Lab. Clin. Med. 77: 470.
Kornberg, A. (1950). Reversible Enzymatic Synthesis of Diphospho- pyridine Nucleotide and Inorganic Phosphate. J. Biol. Chem. 182: 779.
Lenfant, C., Torrance, J., Reynafarje, C. (1971). Shift of the O2-Hb Dissociation Curve at Altitude: Mechanism and Effect. J. Appl. Physiol. 30: 625.
Minakami, S., Suzuki, C., Saito, T., and Yoshikawa, H. (1965) Studies on Erythrocyte Glycolysis I. Determination of the Glycoly tic Intermediates in Human Erythrocytes. J. Biochem. 58: 543.
Noble, N.A., and Brewer, G.J. (1972). Studies of the Metabolic Basis of the DPG-ATP Differences in Genetically-Selected High and Low DPG-ATP Rat Strains. In Proceedings of this Conference.
Oelshlegel, F.J., Brewer, G.J., Penner, J.A., and Schoomaker, E.B. (1972). Enzymatic Mechanisms of Red Cell Adaptation to Anemia. In Proceedings of this Conference.
Rorth, M. (1971). Effect of Acid-Base Disturbances on the Oxygen Transport Function of the Human Red Cell. Acta Anaethesiol. Scand Suppl. 45: 49.
Rorth, M. (1972). Oxygen Affinity of Hemoglobin and Red Cell Metabolism During Exposure to Simulated High Altitude. In Proceedings of this Conference.
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© 1972 Plenum Press, New York
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Moore, L.G., Brewer, G.J., Oelshlegel, F.J. (1972). Red Cell Metabolic Changes in Acute and Chronic Exposure to High Altitude. In: Brewer, G.J. (eds) Hemoglobin and Red Cell Structure and Function. Advances in Experimental Medicine and Biology, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3222-0_31
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DOI: https://doi.org/10.1007/978-1-4684-3222-0_31
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