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Red Cell Metabolic Changes in Acute and Chronic Exposure to High Altitude

  • Lorna Grindlay Moore
  • George J. Brewer
  • Fred J. OelshlegelJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 28)

Abstract

The red blood cell has occupied a central position in studies of how man adapts to high altitudes. With the discovery that the level of DPG has important implications for erythrocyte oxygen affinity, the study of red cell metabolism at high altitudes has taken on new and greater significance. Change in the level of DPG is most certainly related to changes in the levels of other red cell glycolytic intermediates. The appropriate next steps in understanding the mechanism of the increase in DPG are to ascertain which of the enzymes of glycolysis are activated by altitude exposure, and to identify the stimuli which are operating on this enzyme or enzymes. We initiated this next step with studies in Leadville, Colorado, elevation 10,200 feet.

Keywords

High Altitude Hexokinase Activation Chronic Group Acute Group Altitude Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Lorna Grindlay Moore
    • 1
    • 2
  • George J. Brewer
    • 1
    • 2
  • Fred J. OelshlegelJr.
    • 1
    • 2
  1. 1.Department of AnthropologyUniversity of MichiganUSA
  2. 2.Department of Human GeneticsUniversity of MichiganUSA

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