Adjustments of the Oxygen Transport System During Residence at High Altitude

  • L. H. Hartley
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 28)


The systemic O2 transport (product of arterial O2 content and cardiac output) is decreased after ascent to high altitude. The ability to supply the O2 consumption with a lower systemic O2 transport is most marked in individuals who have resided at high altitude for 2 days or more. The development of the capability to lower the mixed venous O2 content to very low values coincides with the development of a rightward shift in the hemoglobin dissociation curve.


Cardiac Output High Altitude Oxygen Transport Dissociation Curve Rightward Shift 


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  1. Astrand, P.O., Cuddy, T.E., Saltin, B., and Stenberg, J. (1964). Cardiac output during submaximal and maximal work. J. Appl. Physiol. 19: 268.PubMedGoogle Scholar
  2. Hartley, L.H. (1971). Effects of high altitude environment on the cardiovascular system of man. J. Am. Med. Ass. 215: 241.CrossRefGoogle Scholar
  3. Lenfant, C. (1971). Shift of the O2 Hb dissociation curve at altitude: mechanism and effect, J. Appl. Physiol. 30: 625.PubMedGoogle Scholar
  4. Saltin, B., Blomquist, G., Mitchell, J.H., Et al (1968). Response to exercise after bed rest and after training. Circulation XXXVIII ( Suppl. No. V II ).Google Scholar
  5. Stenberg, J., Ekblom, B., and Messin, R. (1966). Hemodynamic response to work at simulated altitude, 4,000 m. J. Appl. Physiol. 21: 1589.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • L. H. Hartley
    • 1
  1. 1.Harvard Medical UnitBoston City HospitalBostonUSA

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