Oxygen Affinity Independent Action of Cyanate and 2,3 DPG on Sickling
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Since the Hb S oxygen dissociation curve is shifted to lower partial pressures by carbamylation, it seems important to know whether the cyanate induced in vitro inhibition of sickling is completely or partially due to this increase in oxygen affinity. In order to detect a possible direct interference of carbamyl groups with the aggregation of deoxy-hemoglobin S molecules, sickling was compared in carbamylated and noncarbamylated sickle cells, and the number of sickled forms and the actual oxygen saturations of the hemoglobin were determined simultaneously. These studies have shown that the cyanate effect on sickling is partially independent of the effect of cyanate on oxygen affinity.
KeywordsSickle Cell Anemia Sickle Cell Oxygen Affinity Lower Partial Pressure Carbamyl Phosphate
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