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Carbamyl Phosphate Modification of Hemoglobin S Structure Resulting in Altered Sickling

  • Lorraine M. Kraus
  • Asri Rasad
  • Alfred P. Kraus
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 28)

Abstract

Interest has been elicited in the mechanism involved in the successful reversal and prevention of the sickling of erythrocytes containing Hb SS. Urea, reported by Nalbandian (1971) and by McCurdy (1971), cyanate, reported by Cerami and Manning (1971), and carbamyl phosphate (carbamyl P), reported by Kraus and Kraus (1971) have been successfully used to inhibit the sickling phenomenon. Urea is proposed to act reversibly by interfering with the hydrophobic bonding of hemoglobin molecules, (Murayama, 1971), while cyanate is reported to act irreversibly through the carbamyl ation of the amino terminal valines, (Cerami and Manning, 1971).

Keywords

Sickle Cell Sickle Cell Anemia Patient Cyanic Acid Finger Print Hemoglobin Molecule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • Lorraine M. Kraus
    • 1
    • 2
  • Asri Rasad
    • 1
    • 2
  • Alfred P. Kraus
    • 1
    • 2
  1. 1.Department of BiochemistrySickle Cell Center, University of Tennessee Medical UnitsMemphisUSA
  2. 2.Department of Medicine Hematology SectionSickle Cell Center, University of Tennessee Medical UnitsMemphisUSA

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