Carbamyl Phosphate Modification of Hemoglobin S Structure Resulting in Altered Sickling
Interest has been elicited in the mechanism involved in the successful reversal and prevention of the sickling of erythrocytes containing Hb SS. Urea, reported by Nalbandian (1971) and by McCurdy (1971), cyanate, reported by Cerami and Manning (1971), and carbamyl phosphate (carbamyl P), reported by Kraus and Kraus (1971) have been successfully used to inhibit the sickling phenomenon. Urea is proposed to act reversibly by interfering with the hydrophobic bonding of hemoglobin molecules, (Murayama, 1971), while cyanate is reported to act irreversibly through the carbamyl ation of the amino terminal valines, (Cerami and Manning, 1971).
KeywordsSickle Cell Sickle Cell Anemia Patient Cyanic Acid Finger Print Hemoglobin Molecule
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- McCurdy, P. R., and Mahmood, L. (1971). Urea Therapy for Sickle Cell Disease. Clin. Res. 19: 75.Google Scholar
- Murayama, M. (1971). In “Molecular Aspects of Sickle Cell Hemoglobin” (R. M. Nalbandian, ed.). Chas. C. Thomas Co., Springfield, 111.Google Scholar
- Nalbandian, R. M., Ed. (1971). Molecular Aspects of Sickle Cell Hemoglobin. Charles C. Thomas Co., Springfield, 111.Google Scholar