Abstract
The underlying cause of sickle disease has been shown to be due to the presence of an abnormal hemoglobin in the red blood cell - hemoglobin S (Pauling et al., 1949). When fully oxygenated this hemoglobin behaves much like hemoglobin A, since most of the oxygenated cells from patients with sickle cell disease show normal morphology. There is a variable percentage of the cells that remain sickled even when oxygenated and these are referred to as irreversibly sickled cells.
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© 1972 Plenum Press, New York
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Manning, J.M., Cerami, A., Gillette, P.N., de Furia, F.G., Miller, D.R. (1972). Chemical and Biological Aspects of the Inhibition of Red Blood Cell Sickling by Cyanate. In: Brewer, G.J. (eds) Hemoglobin and Red Cell Structure and Function. Advances in Experimental Medicine and Biology, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3222-0_21
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DOI: https://doi.org/10.1007/978-1-4684-3222-0_21
Publisher Name: Springer, Boston, MA
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