Study of Carbohydrate Metabolism in the Newborn Rat as a Tool for Evaluating Effects of Drugs Administered during Pregnancy

  • R. De Meyer
  • G. Verellen
  • P. Gerard
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 27)


The effects of drugs on fetal development are usually investigated in early pregnancy, during the period of morphogenesis. However, morphogenesis is not the only mode of differentiation. Aside from building new organs, the fetus must also organize new metabolic functions, and for this purpose, new enzymes have to be induced. These aspects of development may be considered as a metabolic differentiation and one may speculate about the effects of drugs on the development of these metabolic functions. An impairment of metabolic differentiation may be considered as a particular aspect of teratogenesis.


Lactic Acid Carbohydrate Metabolism Liver Glycogen Glycogen Level Carbohydrate Store 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    DAWKINS, M.J.R. Ann. N.Y. Acad. Sci. 171: 203, 1963.Google Scholar
  2. 2.
    CAKE, M.H., YEUNG, D. and OLIVER, I.T. Biol. Neonate 18: 183, 1971.PubMedCrossRefGoogle Scholar
  3. 3.
    ROUX, J.M., TORDET-CARIDROIT, C. and CHANEZ, C. Biol. Neonate 18: 58, 1971.PubMedCrossRefGoogle Scholar
  4. 4.
    DE PLAEN, J.L. Aspects dynamiques du métabolisme glucidique chez l’embryon de rat. Action de substances hypoglycémiantes et tératogènes, Maloine. Paris-Arxia, Bruxelles. (1969).Google Scholar
  5. 5.
    STAFFORD, A. and WEATHERALL, A.C. J. Physiol. 153: 457, 1960.PubMedGoogle Scholar
  6. 6.
    ROUX, J.M., TORDET-CARIDROIT, C. and CHANEZ, C. BioZ. Neonate 25: 342, 1970.CrossRefGoogle Scholar
  7. 7.
    SHELLEY, H.J. Brit. Med. Bull. 17: 137, 1961.Google Scholar
  8. 8.
    GOODNER, C.J. and THOMPSON, D.J. Pediat. Res. 2: 443, 1967.CrossRefGoogle Scholar
  9. 9.
    HUNTER, D.J.S. J. Endocr. 45: 367, 1969.PubMedCrossRefGoogle Scholar
  10. 10.
    TAYLOR, P.M. J. Physiol. (London) 254: 153, 1960.Google Scholar
  11. 11.
    WIDDOWSON, E.M. Changes in the composition of the body at birth and their bearing on function and food requirements. In: The adaptation of the newborn infant to extra-uterine life (Nutricia Symposium). Jonxis, J.H.P., Visser, H.K.A. $ Troelstra, J.A. (Eds.), pp. 1–13 (1964).Google Scholar
  12. 12.
    CLARK, C.M., JR., CAHILL•, G.F., JR. and SOELDNER, J.S. Diabetes 17: 362, 1968.PubMedGoogle Scholar
  13. 13.
    DE MEYER, R. Etude experimentale de la glycoregulation gravidique et de l’action teratogène des perturbations du métabolisme glucidique. Thèse univ. Louvain. Bruxelles, Editions Arscia; Paris, Masson et Cie (1961).Google Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • R. De Meyer
    • 1
  • G. Verellen
    • 1
  • P. Gerard
    • 1
  1. 1.Department of PediatricsUniversite Catholique de LouvainLouvainBelgium

Personalised recommendations