A Retrospective Enquiry into Possible Teratogenic Effects of Drugs in Pregnancy
Since Hale’s observation in 1933 that sows fed a diet deficient in vitamin A produce piglets without eyeballs (1), very many physical and chemical agents have been shown to be teratogenic in animals. But the search by epidemiological methods for environmental components in the etiology of human malformations has been less rewarding. There is, however, good evidence that environmental influences are involved, for the incidences of various defects show geographical, secular, and seasonal fluctuations and social class, maternal age, and parity differences. Neither retrospective enquiry (2) nor prospective study (3) has yet been of much value in uncovering the environmental factors responsible, and so far, very few specific agents have been firmly incriminated. It now seems likely that, although environmental influences are undoubtedly important, they will prove to be much more subtle and much less accessible to control than was at one time hoped.
KeywordsSpina Bifida Teratogenic Effect Pyloric Stenosis Retrospective Enquiry Miscellaneous Drug
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