The Effects of Insulin on Fetal Development in “Gestational Diabetes”

  • B. Ismajovich
  • S. Mashiach
  • H. Zakut
  • D. M. Serr
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 27)


There is a close relationship between diabetes and pregnancy (1,2). The metabolic and physiological changes occurring during pregnancy due to ovarian and placental hormone secretion, (increased appetite, the physiological weight gain and the tendency to sodium and fluid retention) may cause great difficulty in the control of maternal diabetes. This increases the incidence of obstetric complications such as toxemia, hydramnion, habitual abortions, sudden fetal death, and difficult and prolonged labor. Maternal diabetes also increases neonatal pathology; newborns tend to be larger, suffer especially from hypoglycemia and respiratory distress syndrome, and in general display a higher frequency of congenital anomalies than do infants of non-diabetic mothers (1–3).


Insulin Therapy Gestational Diabetes Obstetric Complication Obstetric History Maternal Diabetes 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • B. Ismajovich
    • 1
  • S. Mashiach
    • 1
  • H. Zakut
    • 1
  • D. M. Serr
    • 1
  1. 1.Department of Obstetrics and GynecologyThe Chaim Sheba Medical Center Tel-Hashomer and the Tel-Aviv University Medical SchoolIsrael

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