The Effect of Prolonged Chloramphenicol and Oxytetracycline Application on Fetal Development

  • D. Oerter
  • H. J. Merker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 27)


The effects on the embryo of antibiotics and other drugs may be studied using the epidemiological approach. Another method is to observe what happens on the tissue level. Chloramphenicol (CAP) and oxytetracycline (OTC) are known to interfere with the protein synthesis at the 70 S ribosomal level in mitochondria and bacteria, but not at the 80 S ribosomal level in the cytoplasm of cells from multicellular organisms. The increase in the number of these particles during embryonic growth gives us a good opportunity to study the inhibitory effects of CAP on these functions. This approach represents, therefore, a very interesting teratological model. Unfortunately, CAP is very quickly eliminated from the organism. Thus, we have developed a new technique of continuous intravenous infusion over several days, in experiments with rats.


Fetal Development Continuous Intravenous Infusion Embryonic Growth Epidemiological Approach Mitochondrial Division 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    FIRKIN, F. C. LINNANE, A.W. Exp. Cell. Res. 55: 68, 1969.PubMedCrossRefGoogle Scholar
  2. 2.
    KROON, A.M. DeVRIES, H. FERS Letters 3: 208, 1969.CrossRefGoogle Scholar
  3. 3.
    BURTON, K. Biochem. J. 62: 315, 1956.PubMedGoogle Scholar
  4. 4.
    LÖBBECKE, A., SCHULTZE, B. $ MAURER, W. Exp. Cell. Res. 55: 176, 1969.Google Scholar
  5. 5.
    NEUBERT, D., PETERS, H., TESKE, S. ET AL. Naunyn-Schmiedebergs Arch. Pharmak. 268: 235, 1971.CrossRefGoogle Scholar
  6. 6.
    OERTER, D., MERKER, H.J., BASS, R. First meeting of the European Teratology Society, Abstracts, Cardiff, 1971.Google Scholar
  7. 7.
    OERTER, D., MERKER, H.J., BASS, R. Naunyn-Schmiedebergs Arch. Pharmak., Supplement to Vol. 270: R103, 1971.Google Scholar
  8. 8.
    ROODYN, D.B., REIS, P.J., WORK, T.S. Biochem. J., 80:9,1961.PubMedGoogle Scholar
  9. 9.
    SCHNAITMAN, C., ERWIN, V.G., GREENAWALT, J.W. J. Cell. Biol. 32: 719, 1967.PubMedCrossRefGoogle Scholar
  10. 10.
    DE VRIES, H., G KROON, A.M. Biochim. Biophys. Acta 204: 531, 1970.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • D. Oerter
    • 1
  • H. J. Merker
    • 1
  1. 1.Department of PharmacologyAnatomy Free University of BerlinW. Germany

Personalised recommendations