The Use of an Incubator in Detecting Drug-Induced Congenital Malformations
It had been suggested by the U.S. Food and Drug Administration (January, 1966) that for the detection of lethal congenital malformations, the incubation of rabbit fetuses be added to the usual procedure of dissection of fresh fetuses followed by skeletal staining. It was recommended to incubate “one-half of the fetuses for a period of 24 hours, with frequent observations for survival during the first 6 hours”. This means the incubation of fetuses which had been delivered by Caesarean section one day before term (i.e., on day 29 of pregnancy, day 0 being the day of copulation).
KeywordsCleft Palate Bilirubin Concentration Normal Fetus Rabbit Fetus Serum Alkaline Phosphatase Activ
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