Pharmacological Modification of Glutathione and NADP+ Reduction

  • R. Gorodischer
  • S. W. Moses
  • N. Bashan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 27)


Drugs like salicylate and chloramphenicol have been shown experimentally to induce congenital malformations in animals (1). In addition, salicylate is suspected of producing malformations in the human fetus (2). Our main interest in these agents has been to elucidate the hemolytic mechanism they induce in sensitive enzyme-deficient cells. Although the biochemistry of the erythrocyte varies in some respects from the biochemistry of other cells, our data on modification of erythrocyte enzyme activities may well be relevant also to other tissues.


Salicyluric Acid Glutathione Reductase Sodium Salicylate Gentisic Acid Dixon Plot 
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Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • R. Gorodischer
    • 1
  • S. W. Moses
    • 1
  • N. Bashan
    • 1
  1. 1.Pediatric Research LaboratoriesNegev Central Hospital University of the NegevBeer-ShevaIsrael

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